By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Gram-Negative Bacterial Infections. According to news originating from Changchun, People's Republic of China, by NewsRx correspondents, research stated, "Peptidoglycan recognition proteins (PGRPs) are secreted innate immunity pattern recognition molecules. In this study, a new peptidoglycan recognition protein 1 named cnPGRP1 was isolated from an antler base of sika deer Cervus nippon."
Our news journalists obtained a quote from the research from Jilin University, "The antler base antimicrobial proteins (AAP) were subjected to consecutive chromatographic methods connected to Sephadex G-25 gel filtration column (CM) anion-exchange column, and RP-HPLC. The molecular weight of cnPGRP1 was 17.2 kDa under SDS-PAGE, and peptide mass fingerprint analysis by MALDI-TOF-MS as peptidoglycan recognition protein 1 matched to Dasypus novemcinctus. The matched amino acids sequences were RLYEIIQICWPHYRA. Both Gram-positive and Gram-negative bacteria can be killed by cnPGRP1 in the 50-250 mu g/mL range through in vitro."
According to the news editors, the research concluded: "Furthermore, cnPGRP1 has been found to bind Gram-positive bacteria, Gram-negative bacteria, and even fungus."
For more information on this research see: Isolation and characterization of peptidoglycan recognition protein 1 from antler base of sika deer (Cervus nippon). International Journal of Biological Macromolecules, 2014;64():313-318. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
The news correspondents report that additional information may be obtained from W. Jiang, Jilin University, Coll Biol & Agr Engn, Changchun 130022, People's Republic of China. Additional authors for this research include Y.G. Yin, Y.J. Zhou, G.D. He and Y. Qi (see also Gram-Negative Bacterial Infections).
Keywords for this news article include: Asia, Changchun, Mucoproteins, Glycopeptides, Peptidoglycan, Bacterial Polysaccharides, People's Republic of China, Gram-Negative Bacterial Infections
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