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Researchers from Chongqing Medical University Describe Findings in Lipopolysaccharides

May 23, 2014



By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Lipopolysaccharides. According to news reporting out of Chongqing, People's Republic of China, by NewsRx editors, research stated, "Garcinol is a polyisoprenylated benzophenone derivative of Garcinia indica. Recent researches have revealed the antioxidant, anticancer and anti-inflammatory properties of garcinol."

Our news journalists obtained a quote from the research from Chongqing Medical University, "In the present study, the pharmacological effects of garcinol in lipopolysaccharide (LPS)-induced hepatic injury in D-galactosamine (D-Gal)-sensitized mice were investigated. We found that treatment with garcinol significantly decreased serum ALT and AST levels in LPS/D-Gal-exposed mice. These were accomplished with improved histological alterations in liver sections and reduced malondialdehyde (MDA) content in liver homogenates. Garcinol significantly reduced the acetylation level of NF-kappa B, but it had no obvious effects on the elevation of TNF-alpha or IL-6 in plasma or liver tissue. Garcinol significantly attenuated LPS/D-Gal-induced hepatic apoptosis as evidenced by reduced number of TUNEL-positive cells in liver sections. Our experiments also showed that garcinol markedly suppressed the cleavage of caspase-3 and significantly decreased the activities of caspase-3, -8, and -9 in liver tissues. In addition, garcinol obviously reduced the induction of Bax but did not alter the level of Bcl-2."

According to the news editors, the research concluded: "These results indicated that garcinol might provide protective benefits in LPS/D-Gal-induced liver injury through suppressing apoptosis."

For more information on this research see: Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury. International Immunopharmacology, 2014;19(2):373-380. International Immunopharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Immunopharmacology - www.elsevier.com/wps/product/cws_home/621330)

Our news journalists report that additional information may be obtained by contacting Y.P. Jing, Chongqing Med Univ, Lab Stem Cell & Tissue Engn, Chongqing 400016, People's Republic of China. Additional authors for this research include Q. Ai, L. Lin, J. Dai, M.Y. Jia, D. Zhou, Q. Che, J.Y. Wan, R. Jiang and L. Zhang (see also Lipopolysaccharides).

Keywords for this news article include: Asia, Chongqing, Endotoxins, Bacterial Toxins, Lipopolysaccharides, Bacterial Polysaccharides, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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