News Column

Researchers at University of South Dakota Discuss Findings in Nanoparticles

May 20, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Nanoparticles have been published. According to news reporting out of Sioux Falls, South Dakota, by NewsRx editors, research stated, "Curcumin, a natural bioactive polyphenol, has been widely investigated as a conventional medicine for centuries. Over the past two decades, major pre-clinical and clinical trials have demonstrated its safe therapeutic profile but clinical translation has been hampered due to rapid degradation, poor water solubility, bioavailability and pharmaco-kinetics."

Our news journalists obtained a quote from the research from the University of South Dakota, "To overcome such translational issues, many laboratories have focused on developing curcumin nanoformulations for cancer therapeutics. In this review, we discuss the evolution of curcumin nanomedicine in cancer therapeutics, the possible interactions between the surface of curcumin nanoparticles and plasma proteins, the role of nanoparticle-protein complex architecture parameters, and the rational design of clinically useful curcumin nanoformulations."

According to the news editors, the research concluded: "Considering all the biologically relevant phenomena, curcumin nanoformulations can be developed as a new neutraceutical or pharmaceutical agent."

For more information on this research see: Plasma proteins interaction with curcumin nanoparticles: implications in cancer therapeutics. Current Drug Metabolism, 2013;14(4):504-15. (Bentham Science Publishers -; Current Drug Metabolism -

Our news journalists report that additional information may be obtained by contacting M.M. Yallapu, Cancer Biology Research Center, Sanford Research, University of South Dakota, Sioux Falls, SD 57104-0589, United States. Additional authors for this research include M.C. Ebeling, M. Jaggi and S.C Chauhan (see also Nanoparticles).

Keywords for this news article include: Cancer, Oncology, Peptides, Proteins, Sioux Falls, Amino Acids, South Dakota, United States, Nanotechnology, Emerging Technologies, North and Central America, Clinical Trials and Studies.

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Source: Cancer Weekly