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Findings on DNA Research Detailed by Researchers at University of Sevilla

May 20, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on DNA Research are discussed in a new report. According to news reporting originating from Seville, Spain, by NewsRx correspondents, research stated, "The binding of gold nanoparticles capped with N-(2-mercaptopropionyl)glycine (Au@tiopronin) with double-stranded DNA has been investigated and quantified in terms of free energies by using two different approaches. The first approach follows the DNA conformational changes induced by gold nanoparticles using the CD technique."

Our news editors obtained a quote from the research from the University of Sevilla, "The second methodology consists in the use of pyrene-1-carboxaldehyde as a fluorescent probe. This second procedure implies the determination of the 'true' free energy of binding of the probe with DNA, after corrections through solubility measurements. Working at different salt concentrations, the nonelectrostatic and electrostatic components of the binding free energy have been separated. The results obtained revealed that the binding is of nonelectrostatic character, fundamentally."

According to the news editors, the research concluded: "The procedure used in this work could be extended to quantify the binding affinity of other AuNPs/DNA systems."

For more information on this research see: Noncovalent interactions of tiopronin-protected gold nanoparticles with DNA: two methods to quantify free energy of binding. Thescientificworldjournal [electronic Resource], 2014;2014():143645 (see also DNA Research).

The news editors report that additional information may be obtained by contacting R. Prado-Gotor, Dept. of Physical Chemistry, Faculty of Chemistry, University of Sevilla, C, Profesor Garcia Gonzalez S, N, 41012 Sevilla, Spain.

Keywords for this news article include: Spain, Europe, Seville, DNA Research, Nanotechnology, Gold Nanoparticles, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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