News Column

Patent Issued for Optical Fiber Probe

May 7, 2014



By a News Reporter-Staff News Editor at Journal of Engineering -- Indian Institute of Technology Bombay (Mumbai, IN) has been issued patent number 8703505, according to news reporting originating out of Alexandria, Virginia, by VerticalNews editors.

The patent's inventors are Sai, Vemulakonda Venkata Raghavendra (Chennai, IN); Mukherji, Soumyo (Kolkata, IN); Kundu, Tapanendu (Mumbai, IN).

This patent was filed on July 1, 2013 and was published online on April 22, 2014.

From the background information supplied by the inventors, news correspondents obtained the following quote: "Biosensors are becoming more and more popular in the market these days. Optical biosensors are used by analysts and chemists for their ease of operation and compatibility with other types of measurement techniques such as gravimetric and calorimetric techniques. Various attempts have been made to improve the sensitivity and the accuracy of optical biosensors."

Supplementing the background information on this patent, VerticalNews reporters also obtained the inventors' summary information for this patent: "An embodiment herein relate to a sensor comprising an optical fiber having a probe region having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the probe region, and configured to enhance localized surface plasmon resonance. In one aspect, the sensor further comprises an optical setup configured to detect absorbance of radiation in the probe region. In another aspect, at least a part of the probe region comprises a receptor that is configured to bind to an analyte in a sample. In another aspect, the probe region is configured for exposure to a sample. In another aspect, at least a part of the curved portion is substantially U or V shaped.

"In another aspect, at least a part of the probe region further comprises at least a first substantially straight portion that is configured for exposure to a sample and a second substantially straight portion that is configured to avoid exposure to the sample. In another aspect, a part of the substantially straight portion has the nanoparticles thereon. In another aspect, the optical setup comprises a radiation source at one end of the probe and a detector at the other end of the probe. In another aspect, the sensor further comprises a flow cell configured to contain a sample and to surround at least a part of the curved portion.

"In another aspect, the flow cell has a volume of greater than zero microliter and less than 100 microliter. In another aspect, the sensor is configured to detect immobilization of bioreceptors and/or immunocomplex formation. In another aspect, the sensor is configured to detect a presence of an analyte in the sample and to detect a concentration of the analyte in the sample. In another aspect, the nanoparticles comprise a metal exhibiting the surface plasmon resonance.

"Another embodiment relates to a method comprising bending an optical fiber to form a bent optical fiber having a curved portion; and coating nanoparticles on at least a portion of the bent optical fiber to form a probe region. In one aspect, the method further comprises connecting an optical setup configured to detect a difference in refractive index of a sample and a reference material, wherein the optical setup is configured to further detect absorbance of radiation in the bent optical fiber. In another aspect, the optical setup comprises a radiation source connected to one end of the bent optical fiber and a spectrophotometer at the other end of the bent optical fiber. In another aspect, the method further comprises coating at least a part of the probe region with a receptor that binds to an analyte in the sample.

"Another embodiment relates to a method comprising exposing a sample to a bent optical fiber having a curved portion and detecting a difference in refractive index of the sample and a reference material. In one aspect, the method, further comprises detecting a presence of an analyte in the sample and detecting a concentration of the analyte in the sample. In another aspect, the analyte comprises a biological molecule or a non-biological molecule.

"The foregoing summary is illustrative only and is not intended to be in any way limiting. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features will become apparent by reference to the drawings and the following detailed description."

For the URL and additional information on this patent, see: Sai, Vemulakonda Venkata Raghavendra; Mukherji, Soumyo; Kundu, Tapanendu. Optical Fiber Probe. U.S. Patent Number 8703505, filed July 1, 2013, and published online on April 22, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=90&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=4466&f=G&l=50&co1=AND&d=PTXT&s1=20140422.PD.&OS=ISD/20140422&RS=ISD/20140422

Keywords for this news article include: Biosensing, Nanoparticle, Bioengineering, Bionanotechnology, Nanobiotechnology, Emerging Technologies, Indian Institute of Technology Bombay.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Journal of Engineering


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters