ENP Newswire -
Release date- 29042014 - The
Research, led by Dr
The strategic funding from the
The two Nottingham projects funded by the NC3Rs 'Imaging Technology Development for the
1. Ultrasound mediated bioluminescence tomography for high sensitivity, high spatial resolution 3D imaging led by
Improving animal research and outcomes for patients
Dr Grabowska said: 'Our work aims to develop more refined pre-clinical models of cancer which can be used, during the early phases of drug development, to predict which anti-cancer molecules are most likely to be beneficial in patients. This funding will enable us to develop advanced imaging tools that will enhance the information that can be gained from the models, including real-time measurement of growth and response to drugs. Ultimately, this should accelerate progress in moving effective drugs into the clinic where they can improve outcomes for patients.'
Researchers estimate that the refined pre-clinical cancer models made possible by this new imaging technique could reduce animal use in cancer studies by approximately 170,000 per year.
Replacing, reducing and refining the use of animals in science
The NC3Rs funding will support five research projects to increase the utility of a broad spectrum of imaging techniques, including bioluminescence, radio labelling and implantable technology. The projects aim to extend the use of imaging technologies in applications not currently possible with a view to improving animal research, for example by using non-invasive imaging, which minimises suffering, or longitudinal imaging throughout the study, which reduces the number of animals required.
Commenting on the awards, Dr
'The potential for technological development to replace, reduce and refine the use of animals in science is now well recognised across the research community. Preclinical imaging offers an opportunity for researchers to greatly reduce and refine animal use through longitudinal studies and identifying earlier endpoints to reduce suffering. However its application is often restricted by limitations with the current technologies available. This strategic funding allows the NC3Rs to target key areas identified by the research community where the development and application of new imaging techniques could have a profound impact on animal use and science.'
Background to the funding call
.Animal handling and welfare assessment
.Tracking cell fate and distribution
.3D gene expression profiling
.Imaging bioengineered tissues
.Molecular imaging of biodistribution
.Improving sensitivity and resolution
.Phenotyping genetically modified mice.
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