News Column

Study Results from National Chemical Laboratory Broaden Understanding of Antibiotics

May 7, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Maharashtra, India, by NewsRx journalists, research stated, "Ciprofloxacin was conjugated with polylactide (PLA) via the secondary amine group of the piperazine ring using PLA and 7-(4-(2-Chloroacetyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. Zinc prolinate, a biocompatible catalyst was synthesized, characterized, and used in ring opening polymerization of L-lactide."

The news correspondents obtained a quote from the research from National Chemical Laboratory, "Five different kinds of OH-terminated poly(L-lactide) (two-, three-, four-, six-arm, star-shaped) homopolymers were synthesized by ring opening polymerization of L-lactide in the presence of dodecanol, glycerol, pentaerythritol, dipentaerythritol as initiator and zinc prolinate as a catalyst. The structures of the polymers and conjugates were thoroughly characterized by means of gel permeation chromatography, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and nuclear magnetic resonance spectroscopy. PLA (molecular weight = 100,000) and ciprofloxacin conjugated PLA were used for fabrication of nonwoven nanofiber mat (diameter ranges; 150-400 nm) having pore size (62-102 nm) using electrospinning. The microbiological assessment shows that the release of ciprofloxacin possesses antimicrobial activity. The drug-release behavior of the mat was studied to reveal potential application as a drug delivery system. The result shows that the ciprofloxacin release rates of the PLA conjugate nonwoven nanofiber mat could be controlled by the drug loading content and the release medium."

According to the news reporters, the research concluded: "The development of a biodegradable ciprofloxacin system, based on nonwoven nanofiber mat, should be of great interest in drug delivery systems."

For more information on this research see: Synthesis of ciprofloxacin-conjugated poly(L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation. International Journal of Nanomedicine, 2014;9():1463-1477. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting S.P. Parwe, Natl Chem Lab, Polymer Sci & Engn Div, Pune 411008, Maharashtra, India. Additional authors for this research include P.N. Chaudhari, K.K. Mohite, B.S. Selukar, S.S. Nande and B. Garnaik.

Keywords for this news article include: Asia, Antibacterial, Antibiotics, Antimicrobials, India, Lactates, Maharashtra, Lactic Acid, Drugs and Therapies, Drug Delivery Systems

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Source: Biotech Week

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