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Studies from Zhejiang University of Technology Have Provided New Data on Mannitol Therapy

May 7, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news originating from Hangzhou, People's Republic of China, by NewsRx correspondents, research stated, "The purpose of this work is to prepare a formulation using mannitol coupling Camptothecin (CPT) nanoparticles (CPT-NPs) to circumvent the difficult solubilization practice based on central composite experimental statistical design. CPT-NPs were prepared with a high-pressure homogenization technique method."

Our news journalists obtained a quote from the research from the Zhejiang University of Technology, "The independent variables considered for the optimization of CPT-NPs were percentage of CPT in raw material (CPT and mannitol), concentration of CPT in working liquid, cycles numbers and homogenizer pressure for drug loading efficiency, particle size and polyclispersity index. Analysis of variance (ANOVA) statistical test was used to assess the optimization. The optimized CPT-NPs showed an appropriate drug loading efficiency (18.09 2.13%), a homogeneous particle size (165.33 + 37.23 nm) and a low polydispersity index (0.29 +/- 0.01). The CPT-NPs group show higher inhibition ratio (79.95%) of H22 tumor growth in vivo compared with TM. and CPT at the same close. Changes in mice body weight demonstrate CPT-NPs have the lower toxicity. The results of biodistribution studies indicated the obviously superiority of CPT-NPs in increasing the accumulation of CPT within tumor."

According to the news editors, the research concluded: "Overall, CPT-NPs under optimum conditions are considered to be potentially feasible to overcome formulation challenges for drug delivery."

For more information on this research see: Preparation, formula optimization and antitumor actions of mannitol coupling camptothecin nanoparticles. International Journal of Pharmaceutics, 2014;465(1-2):360-367. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; International Journal of Pharmaceutics -

The news correspondents report that additional information may be obtained from Z.C. Wang, Zhejiang University of Technology, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, People's Republic of China. Additional authors for this research include Q.Y. Li, X.H. Zhao, B.H. Sun, Q.C. Zhu, W.Q. Gao and C.L. Hu (see also Drugs and Therapies).

Keywords for this news article include: Asia, Pharmaceuticals, Hangzhou, Mannitol, Diuretics, Nanoparticle, Nanotechnology, Sugar Alcohols, Drugs and Therapies, Cardiovascular Agents, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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