News Column

Studies from University of Munich Have Provided New Information about Phagocytosis

May 9, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Phagocytosis. According to news reporting originating in Munich, Germany, by NewsRx journalists, research stated, "Particle geometry of micro-and nanoparticles has been identified as an important design parameter to influence the interaction with cells such as macrophages. A head to head comparison of elongated, non-spherical and spherical micro- and nanoparticles with and without PEGylation was carried out to benchmark two phagocytosis inhibiting techniques."

The news reporters obtained a quote from the research from the University of Munich, "J774.A1 macrophages were incubated with fluorescently labeled PLGA micro- and nanoparticles and analyzed by confocal laser scanning microscope (CLSM) and flow cytometry (FACS). Particle uptake into macrophages was significantly reduced upon PEGylation or elongated particle geometry."

According to the news reporters, the research concluded: "A combination of both, an elongated shape and PEGylation, had the strongest phagocytosis inhibiting effect for nanoparticles."

For more information on this research see: Influence of particle geometry and PEGylation on phagocytosis of particulate carriers. International Journal of Pharmaceutics, 2014;465(1-2):159-164. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

Our news correspondents report that additional information may be obtained by contacting R. Mathaes, University of Munich, Dept. of Pharm Pharmaceut Technol & Biopharmaceut, D-81377 Munich, Germany. Additional authors for this research include G. Winter, A. Besheer and J. Engert (see also Phagocytosis).

Keywords for this news article include: Munich, Europe, Germany, Immunology, Macrophages, Nanoparticle, Phagocytosis, Myeloid Cells, Nanotechnology, Emerging Technologies, Connective Tissue Cells, Mononuclear Phagocyte System

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Source: Health & Medicine Week