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Researchers' Work from Nanjing University of Technology Focuses on Dicarboxylic Acids

May 6, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Dicarboxylic Acids. According to news reporting originating from Nanjing, People's Republic of China, by NewsRx correspondents, research stated, "To enhance succinic acid formation during xylose fermentation in Escherichia coli, overexpression of ATP-forming phosphoenolpyruvate carboxykinase (PEPCK) from Bacillus subtilis 168 in an ldhA, pflB, and ppc deletion strain resulted in a significant increase in cell mass and succinic acid production."

Our news editors obtained a quote from the research from the Nanjing University of Technology, "However, BA204 displays a low yield of glucose fermentation and sequential glucose-xylose utilization under regulation by the phosphotransferase system (PTS). To improve the capability of glucose fermentation and simultaneously consume sugar mixture for succinic acid production, a pflB, ldhA, ppc, and ptsG deletion strain overexpressing ATP-forming PEPCK, named E. coli BA305, was constructed."

According to the news editors, the research concluded: "As a result, after 120 h fed-batch fermentation of sugarcane bagasse hydrolysate, the dry cell weight and succinic acid concentration in BA305 were 4.58 g L(-1) and 39.3 g L(-1), respectively."

For more information on this research see: Efficient succinic acid production from lignocellulosic biomass by simultaneous utilization of glucose and xylose in engineered Escherichia coli. Bioresource Technology, 2013;149():84-91. (Elsevier -; Bioresource Technology -

The news editors report that additional information may be obtained by contacting R. Liu, State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, People's Republic of China. Additional authors for this research include L. Liang, F. Li, M. Wu, K. Chen, J. Ma, M. Jiang, P. Wei and P. Ouyang (see also Dicarboxylic Acids).

Keywords for this news article include: Asia, Nanjing, Succinic Acids, Escherichia coli, Dicarboxylic Acids, Enterobacteriaceae, Gram Negative Bacteria, People's Republic of China.

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Source: Life Science Weekly

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