News Column

Researchers from Sichuan University Report New Studies and Findings in the Area of Drug Delivery Systems

May 7, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news reporting originating in Chengdu, People's Republic of China, by NewsRx journalists, research stated, "A novel type of nanovehicle (NV) based on stimuli-responsive supramolecular peptide-amphiphiles (SPAs, dendritic poly (L-lysine) non-covalently linked poly (L-leucine))is developed for intracellular drug delivery. To determine the pH-dependent mechanism, the supramolecular peptide-amphiphile system (SPAS)is investigated at different pH conditions using a variety of physical and chemical approaches."

The news reporters obtained a quote from the research from Sichuan University, "The pH-triggered disassembly of SPAS can be attributed to the disappearance of non-covalent interactions within SPAs around the isoelectric point of poly (L-leucine). SPAS is found to encapsulate guest molecules at pH 7.4 but release them at pH 6.2. In this way, SPASis able to act as a smart NV to deliver its target to tumor cells using intracellular pH as a trigger. The DOX-loaded NVsare approximately 150 nm in size. In vitro release profiles and confocal laser scanning microscopy (CLSM) images of HepG2 cells confirm that lower pH conditions can trigger the disassembly of NVs and so achieve pH-dependent intracellular DOX delivery. In vitro cytotoxicity of the DOX-loaded NVs to HepG2 cells demonstrate that the smart NVs enhance the efficacy of hydrophobic DOX."

According to the news reporters, the research concluded: "Fluorescence-activated cell sorting (FACS) and CLSM results show that the NVs can enhance the endocytosis of DOX into HepG2 cells considerably and deliver DOX to the nuclei."

For more information on this research see: Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide-Amphiphiles for Efficient Intracellular Drug Delivery. Small, 2014;10(6):1133-1140. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Small -

Our news correspondents report that additional information may be obtained by contacting X.H. Xu, Sichuan University, Natl Engn Res Center Biomat, Chengdu 610064, Sichuan, People's Republic of China. Additional authors for this research include Y.K. Li, H.P. Li, R. Liu, M.M. Sheng, B. He and Z.W. Gu (see also Drugs and Therapies).

Keywords for this news article include: Asia, Chengdu, Nanotechnology, Supramolecular, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China

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Source: Biotech Week