News Column

Researchers from King Saud University Report Recent Findings in Fibroblasts

May 6, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Fibroblasts are presented in a new report. According to news reporting from Riyadh, Saudi Arabia, by NewsRx journalists, research stated, "Silica (E551) is commonly used as an anti-caking agent in food products. The morphology and the dimension of the added silica particles are not, however, usually stated on the food product label."

The news correspondents obtained a quote from the research from King Saud University, "The food industry has adapted nanotechnology using engineered nanoparticles to improve the quality of their products. However, there has been increased debate regarding the health and safety concerns related to the use of engineered nanoparticles in consumer products. In this study, we investigated the morphology and dimensions of silica (E551) particles in food. The silica content of commercial food products was determined using inductively coupled plasma optical emission spectrometry. The result indicates that 2.74-14. 45 mu g/g silica was found in commercial food products; however, the daily dietary intake in increase causes adverse effects on human health. E551 was isolated from food products and the morphology, particle size, crystalline nature, and purity of the silica particles were analyzed using XRD, FTIR, TEM, EDX and DLS. The results of these analyses confirmed the presence of spherical silica nanoparticles (of amorphous nature) in food, approximately 10-50 nm in size. The effects of E551 on human lung fibroblast cell viability, intracellular ROS levels, cell cycle phase, and the expression levels of metabolic stress-responsive genes (CAT, GSTA4, TNF, CYP1A, POR, SOD1, GSTM3, GPX1, and GSR1) were studied. The results suggest that E551 induces a dose-dependent cytotoxicity and changes in ROS levels and alters the gene expression and cell cycle. Treatment with a high concentration of E551 caused significant cytotoxic effects on WI-38 cells."

According to the news reporters, the research concluded: "These findings have implications for the use of these nanoparticles in the food industry."

For more information on this research see: Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells. Cell Biology and Toxicology, 2014;30(2):89-100. Cell Biology and Toxicology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer -; Cell Biology and Toxicology -

Our news journalists report that additional information may be obtained by contacting J. Athinarayanan, King Saud Univ, Dept. of Chem, Coll Sci, Riyadh 11451, Saudi Arabia. Additional authors for this research include V.S. Periasamy, M.A. Alsaif, A.A. Al-Warthan and A.A. Alshatwi (see also Fibroblasts).

Keywords for this news article include: Asia, Riyadh, Engineering, Fibroblasts, Saudi Arabia, Nanoparticle, Nanotechnology, Emerging Technologies, Connective Tissue Cells

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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