By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biomedicine and Biomedical Engineering. According to news reporting out of Warsaw, Poland, by NewsRx editors, research stated, "The rate of hydrolytic degradation of tissue-engineered scaffolds made from bioresorbable polyesters is dependent on several factors. Some are related to the properties of the degrading polymeric material, but others are related to the geometry of the porous structure and the operating environment."
Our news journalists obtained a quote from the research from the Warsaw University of Technology, "It is well known that the rate of hydrolytic degradation of a given object, porous or nonporous, is lower when it is exposed to dynamic conditions, a flowing medium, than when it operates in static conditions. The most likely reason is the more efficient removal of the acidic degradation products from the vicinity of the polymeric material when it is operating in a flowing medium. In this article, we present a new phenomenological reaction-diffusion model of aliphatic polymer degradation. The model can be used to predict the significance of various factors in in vitro degradation tests, with particular reference to the flow of the degradation medium, and the frequency of medium replacement in the case of static conditions. The developed model was used to simulate the degradation of poly(dl-lactide-co-glycolide) scaffolds with different porosities subjected to static and dynamic testing conditions. The results confirm that the porosity of the scaffold had a significant influence on the degradation rate. It was shown that the combination of dynamic conditions and high porosity effectively reduced the mass loss and molecular weight loss of the degrading polymer."
According to the news editors, the research concluded: "However, the effect of changes in the velocity of the flowing medium had a negligible effect on the rate of degradation."
For more information on this research see: Modeling of the Degradation Kinetics of Biodegradable Scaffolds: The Effects of the Environmental Conditions. Journal of Applied Polymer Science, 2014;131(11):362-368. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)
Our news journalists report that additional information may be obtained by contacting M.K. Heljak, Warsaw University of Technology, Fac Mat Sci & Engn, PL-02507 Warsaw, Poland. Additional authors for this research include W. Swieszkowski and K.J. Kurzydlowski (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Warsaw, Poland, Europe, Bioengineering
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