By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on DNA Research. According to news reporting originating in Tempe, Arizona, by NewsRx journalists, research stated, "Controlled nucleation of nanoscale building blocks by geometrically defined seeds implanted in DNA nanoscaffolds represents a unique strategy to study and understand the dynamic processes of molecular self-assembly. Here we utilize a two-dimensional DNA origami frame with a hollow interior and selectively positioned DNA hybridization seeds to control the self-assembly of DNA tile building blocks, where the small DNA tiles are directed to fill the interior of the frame through prescribed sticky end interactions."
The news reporters obtained a quote from the research from Arizona State University, "This design facilitates the construction of DNA origami/array hybrids that adopt the overall shape and dimensions of the origami frame, forming a 2D array in the core consisting of a large number of simple repeating DNA tiles. The formation of the origami/array hybrid was characterized with atomic force microscopy, and the nucleation dynamics were monitored by serial AFM scanning and fluorescence spectroscopy, which revealed faster kinetics of growth within the frame as compared to growth without the presence of a frame."
According to the news reporters, the research concluded: "Our study provides insight into the fundamental behavior of DNA-based self-assembling systems."
For more information on this research see: Controlled Nucleation and Growth of DNA Tile Arrays within Prescribed DNA Origami Frames and Their Dynamics. Journal of the American Chemical Society, 2014;136(10):3724-3727. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
Our news correspondents report that additional information may be obtained by contacting W. Li, Arizona State University, Biodesign Inst, Center Mol Design & Biomimicry, Tempe, AZ 85287, United States. Additional authors for this research include Y. Yang, S.X. Jiang, H. Yan and Y. Liu (see also DNA Research).
Keywords for this news article include: Tempe, Arizona, DNA Research, United States, North and Central America
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