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New Capillary Electrophoresis Study Findings Recently Were Reported by Researchers at Khon Kaen University

May 6, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Capillary Electrophoresis is the subject of a report. According to news reporting originating in Khon Kaen, Thailand, by NewsRx journalists, research stated, "Interface-free two-dimensional heart-cutting capillary electrophoresis is typically used to purify/concentrate and separate a single target fraction. Here, we demonstrate the simultaneous stacking and orthogonal separation of target fractions that belong to two different classes of compounds."

The news reporters obtained a quote from the research from Khon Kaen University, "The cationic species were first analyzed by capillary zone electrophoresis using an electrolyte of low pH in a fused-silica capillary. The neutrals that remained inside the capillary after the first dimension analysis were then separated by micellar electrokinetic chromatography using sodium dodecyl sulfate micelles that were electrophoretically introduced into the capillary. The suppression of electro-osmotic flow using low pH was essential in shifting the separation selectivity from electrophoresis to electrokinetic chromatography. Two approaches to stacking based on the solubility of the species present were developed. Stacking was achieved during the first dimension analysis via sweeping and/or analyte focusing by micelle collapse. Two artificial mixtures (eight cationic drugs/five neutral steroids, and three quaternary ammonium/three neutral organophosphate pesticides) were successfully analyzed with sensitivity enhancement factors from 15 to 100."

According to the news reporters, the research concluded: "Some analytical parameters and application to a spiked real water sample were also studied."

For more information on this research see: Stacking and Separation of Neutral and Cationic Analytes in Interface-Free Two-Dimensional Heart-Cutting Capillary Electrophoresis. Analytical Chemistry, 2014;86(6):3159-3166. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news correspondents report that additional information may be obtained by contacting C. Kukusamude, Khon Kaen University, Fac Sci, Center Excellence Innovat Chem, Khon Kaen 40002, Thailand. Additional authors for this research include S. Srijaranai and J.P. Quirino (see also Capillary Electrophoresis).

Keywords for this news article include: Asia, Thailand, Khon Kaen, Nanotechnology, Electrokinetics, Emerging Technologies, Capillary Electrophoresis

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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