News Column

Maastricht University Hospital Describes Findings in Alzheimer Disease

May 9, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Neurodegenerative Diseases have been published. According to news reporting originating from Maastricht, Netherlands, by NewsRx correspondents, research stated, "The present study compares four different structural magnetic resonance imaging techniques used to measure gray matter (GM) atrophy in Alzheimer's disease (AD): manual and automated volumetry, cortical thickness (CT) and voxel-based morphometry (VBM). These techniques are used interchangeably in AD research and thus far it is unclear which technique is superior in detecting abnormalities early in the disease process. 18 healthy participants without any memory impairment, 18 patients with MCI, and 17 patients with mild AD were included and between-group differences were investigated in AD signature regions (areas in the prefrontal cortex (PFC), medial temporal lobe (MTL) and posterior parietal cortex (PPC))."

Our news editors obtained a quote from the research from Maastricht University Hospital, "Both manual volumetric measurements and VBM were able to detect GM atrophy in the early stages (differentiation controls and MCI), mainly in the MTL. In the early phase, automated volumetric measurements showed GM differences in the PPC but not in the MTL. In our sample, CT measurements were not sensitive for group differences in the early stages. PFC regions showed abnormalities in the later stages (controls vs AD) when manual volumetric measurements or VBM are employed. Manual volumetric measurements together with VBM are preferred techniques for assessing GM differences showing abnormalities in most of the investigated regions, with a predominance of the MTL in the early phase. Automated FreeSurfer volumetric measurements show similar performances in the early phase, displaying group differences in the PPC but not in MTL regions."

According to the news editors, the research concluded: "Measurements of CT are less sensitive in the MCI stage and its sensitivity is restricted to the MTL and PPC regions in later stages of the disease (AD)."

For more information on this research see: Sensitivity of different MRI-techniques to assess gray matter atrophy patterns in Alzheimer's disease is region-specific. Current Alzheimer Research, 2013;10(9):940-51. (Bentham Science Publishers -; Current Alzheimer Research -

The news editors report that additional information may be obtained by contacting L. Clerx, Dept. of Psychiatry and Neuropsychology, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands. Additional authors for this research include H.I. Jacobs, S. Burgmans, E.H. Gronenschild, H.B. Uylings, C. Echavarri, P.J. Visser, F.R. Verhey and P. Aalten (see also Neurodegenerative Diseases).

Keywords for this news article include: Europe, Dementia, Maastricht, Netherlands, Tauopathies, Brain Diseases, Alzheimer Disease, Neurodegenerative Diseases, Central Nervous System Diseases.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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