News Column

Findings from Durham University Broaden Understanding of Carboxylic Ester Hydrolases

May 6, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news originating from Durham, United Kingdom, by NewsRx correspondents, research stated, "Biotechnology involves applying enzymes in organic synthesis to convert non-natural substrates into enantiomerically pure products under mild reaction conditions. Non-natural substrates are often lipophilic molecules that can hardly be accessed and converted by enzymes in their natural aqueous environment."

Our news journalists obtained a quote from the research from Durham University, "Bicontinuous microemulsions provide a spongelike nanostructure with a large interfacial area between aqueous and oil domains, which makes them valuable alternative reaction media. In the present study, we introduced lipase B from Candida antarctica into a bicontinuous microemulsion of composition H2O/NaCl- n-octane-pentaethylene glycol monodecylether (C10E5). Phase behavior, partitioning studies, and pulsed-field-gradient NMR measurements revealed that the lipase is mostly adsorbed at the microemulsions interface. Phase diagrams showed a maximum in efficiency with increasing amount of lipase added to the water phase of the microemulsion. It was observed that the ratio between the mass of lipase that is introduced into the system and the mass of lipase that is located at the interface stays constant."

According to the news editors, the research concluded: "Self-diffusion coefficients of all components showed that the presence of the lipase is not influencing the bicontinuity of the microemulsion."

For more information on this research see: Physicochemical Aspects of Lipase B from Candida antarctica in Bicontinuous Microemulsions. Langmuir, 2014;30(11):2993-3000. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Langmuir -

The news correspondents report that additional information may be obtained from M. Subinya, University of Durham, Dept. of Chem, Durham DH1 3LE, United Kingdom. Additional authors for this research include A.K. Steudle, B. Nestl, B. Nebel, B. Hauer, C. Stubenrauch and S. Engelskirchen (see also Enzymes and Coenzymes).

Keywords for this news article include: Durham, Europe, Lipase, United Kingdom, Enzymes and Coenzymes, Carboxylic Ester Hydrolases

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Source: Life Science Weekly

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