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ProNAi Therapeutics Gets $59.5 Million in Series D Financing

April 29, 2014

ProNAi Therapeutics, Inc., a developer of novel nucleic acid therapeutics, announced the closing of an oversubscribed $59.5 million Series D financing.

According to a release, the round was led by Vivo Capital of Palo Alto, CA and included other new investors Frazier Healthcare Ventures, OrbiMed Advisors, Adams Street Partners, RA Capital Management, Caxton Alternative Management, Hopen Life Science Ventures, Sectoral Asset Management, and Janus Capital Management. Existing investors including Capital Midwest Fund, Apjohn Ventures Fund, Amherst Fund, and Grand Angels also participated in the financing round. For the transaction, Jefferies served as the sole placement agent and Honigman Miller Schwartz and Cohn served as legal advisor to the company.

"This financing is a transformative milestone in ProNAi's ten year history, and follows the clinical results recently reported by the company and its clinical investigators. We are pleased to have attracted such an experienced and well regarded group of investors. Their support of this financing will allow us to execute our plans with greater speed and broader reach." said Mina Sooch MBA, President and Chief Executive Officer of ProNAi. "Since our founding, we have been committed to the development of novel nucleic acid therapeutics designed to treat various genetically defined diseases, initially in certain cancers, with a proprietary technology we have termed DNAi. Our lead drug candidate, PNT2258, targets the BCL2 gene. The drug has shown early evidence of systemic anti-tumor effect when administered to patients whose cancers express the BCL2 genetic target. With the PNT2258 formulation, ProNAi has overcome the nucleic acid delivery challenges faced by competitive programs by incorporating our unique single stranded, chemically unmodified DNAi oligonucleotide into a differentiated lipid delivery system (SMARTICLES). The combination of genetic specificity with effective IV delivery provides us the opportunity to construct potential therapies with a broad range of targets in oncology and other diseases."

As part of the Series D financing, Albert Cha, MD, PhD (Vivo Capital), Peter Thompson, MD (OrbiMed Advisors), and James Topper, MD, PhD (Frazier Healthcare Ventures) have joined ProNAi's board of directors along with current members Chairman Donald Parfet (Apjohn Ventures) and Alvin Vitangcol (Capital Midwest Fund).

"ProNAi is developing a new class of DNAi therapeutics that has demonstrated promising results in lymphoma patients," said Dr. Albert Cha. "We are excited about the opportunity to move PNT2258 forward and further develop the company's pipeline."

The Series D funding will be used to advance PNT2258 in several Phase II clinical studies in patients with relapsed or treatment refractory non-Hodgkin's lymphoma including those with diffuse large B-cell lymphoma (DLBCL),Richter's transformation, and follicular lymphoma (FL). Proceeds will also be used to support drug manufacturing, advance development of preclinical drug candidates, and build ProNAi's organization in Michigan.

PNT2258 is a 24-base, single-stranded, chemically-unmodified DNA oligonucleotide called PNT100 that is encapsulated in a specialized anionic and pH "tunable" liposome (SMARTICLES owned by Marina Biotech, Inc. and licensed exclusively to ProNAi solely in the field of DNAi).

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