News Column

Findings from Chinese Academy of Science Yields New Data on General Science

May 2, 2014

By a News Reporter-Staff News Editor at Science Letter -- A new study on Science is now available. According to news reporting from Xi'an, People's Republic of China, by NewsRx journalists, research stated, "Optical microscopy plays an essential role in biological studies due to its capability and compatibility of non-contact, minimally invasive observation and measurement of live specimens. However, the conventional optical microscopy only has a spatial resolution about 200 nm due to the Abbe diffraction limit, and also lacks the ability of three-dimensional imaging."

The news correspondents obtained a quote from the research from the Chinese Academy of Science, "Super-resolution far-field optical microscopy based on special illumination schemes has been dramatically developed over the last decade. Among them, only the structured illumination microscopy (SIM) is of wide-field geometry that enables it easily compatible with the conventional optical microscope. In this article, the principle of SIM was introduced in terms of point spread function (PSF) and optical transform function (OTF) of the optical system. The SIM for super-resolution (SIM-SR) proposed by Gustafsson et al. and the SIM for optical sectioning (SIM-OS) proposed by Neil et al. are the most popular ones in the research community of microscopy. They have the same optical configuration, but with different data post-processing algorithms. We mathematically described the basic theories for both of the SIMs, respectively, and presented some numerical simulations to show the effects of super-resolution and optical sectioning. Various approaches to generation of structured illumination patterns were reviewed. As an example, a SIM system based on DMD-modulation and LED-illumination was demonstrated. A lateral resolution of 90 nm was achieved with gold nano-particles."

According to the news reporters, the research concluded: "The optical sectioning capability of the microscope was demonstrated with Golgi-stained mouse brain neurons, and the sectioning strength of 930 nm was obtained."

For more information on this research see: Structured illumination microscopy for super-resolution and optical sectioning. Chinese Science Bulletin, 2014;59(12):1291-1307. Chinese Science Bulletin can be contacted at: Science Press, 16 Donghuangchenggen North St, Beijing 100717, Peoples R China. (World Scientific Publishing -; Chinese Science Bulletin -

Our news journalists report that additional information may be obtained by contacting D. Dan, Chinese Academy Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, People's Republic of China. Additional authors for this research include B.L. Yao and M. Lei (see also Science).

Keywords for this news article include: Asia, Xi'an, Science, People's Republic of China

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Source: Science Letter