News Column

University of Pittsburgh Details Findings in Clinical Trials and Studies

April 28, 2014

By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Clinical Research. According to news originating from Pittsburgh, Pennsylvania, by NewsRx correspondents, research stated, "Full-field optical coherence tomography (FF-OCT) is a new noninvasive imaging technique that can see down to the cellular level without tissue preparation or contrast agents. To use FF-OCT to image Mohs micrographic surgery specimens and verify the ability of a dermatopathologist to identify or exclude malignancy."

Our news journalists obtained a quote from the research from the University of Pittsburgh, "Two Mohs surgeons supplied 18 Mohs sections from 11 patients. Each section was scanned using the FF-OCT, and a dermatopathologist blinded to the diagnosis examined the images for malignancy. The FF-OCT images were then compared with the intraoperative hematoxylin and eosin (H&E)-stained frozen sections for concordance. All 9 FF-OCT images interpreted as negative for malignancy were in agreement with the H&E frozen sections. Six of the remaining FF-OCT images were correctly interpreted as positive for malignancy, and three were deferred because malignancy could not be confirmed or excluded. Malignancy in Mohs sections can correctly be identified or excluded using FF-OCT."

According to the news editors, the research concluded: "Although not ready for clinical use in its current state, FF-OCT has the potential to be incorporated into the Mohs workflow in the future."

For more information on this research see: Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study. Dermatologic Surgery, 2014;40(3):266-274. Dermatologic Surgery can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Dermatologic Surgery -

The news correspondents report that additional information may be obtained from J.R. Durkin, University of Pittsburgh, Medical Center, Dept. of Dermatol, Pittsburgh, PA 15213, United States. Additional authors for this research include J.L. Fine, H. Sam, M. Pugliano-Mauro and J. Ho (see also Clinical Research).

Keywords for this news article include: Surgery, Pittsburgh, Pennsylvania, United States, Clinical Research, Imaging Technology, North and Central America, Clinical Trials and Studies, Optical Coherence Tomography

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Source: Clinical Trials Week