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New Findings Reported from Drexel University Describe Advances in Risk Management

May 2, 2014



By a News Reporter-Staff News Editor at Insurance Weekly News -- Data detailed on Risk Management have been presented. According to news originating from Philadelphia, Pennsylvania, by VerticalNews correspondents, research stated, "Leptospirosis is a preeminent zoonotic disease concentrated in tropical areas, and prevalent in both industrialized and rural settings. Dose-response models were generated from 22 data sets reported in 10 different studies."

Our news journalists obtained a quote from the research from Drexel University, "All of the selected studies used rodent subjects, primarily hamsters, with the predominant endpoint as mortality with the challenge strain administered intraperitoneally. Dose-response models based on a single evaluation postinfection displayed median lethal dose (LD50) estimates that ranged between 1 and 10(7) leptospirae depending upon the strain's virulence and the period elapsed since the initial exposure inoculation. Twelve of the 22 data sets measured the number of affected subjects daily over an extended period, so dose-response models with time-dependent parameters were estimated. Pooling between data sets produced seven common dose-response models and one time-dependent model. These pooled common models had data sets with different test subject hosts, and between disparate leptospiral strains tested on identical hosts. Comparative modeling was done with parallel tests to test the effects of a single different variable of either strain or test host and quantify the difference by calculating a dose multiplication factor."

According to the news editors, the research concluded: "Statistical pooling implies that the mechanistic processes of leptospirosis can be represented by the same dose-response model for different experimental infection tests even though they may involve different host species, routes, and leptospiral strains, although the cause of this pathophysiological phenomenon has not yet been identified."

For more information on this research see: Classic Dose-Response and Time Postinoculation Models for Leptospira. Risk Analysis, 2014;34(3):465-484. Risk Analysis can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Risk Analysis - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1539-6924)

The news correspondents report that additional information may be obtained from T. Watanabe, Drexel University, Dept. of Civil Arch & Environm Engn, Philadelphia, PA 19104, United States. Additional authors for this research include S.S. Teske and C.N. Haas.

Keywords for this news article include: Philadelphia, Pennsylvania, United States, Risk Management, North and Central America

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Source: Insurance Weekly News