News Column

Findings from University of Cairo Provides New Data about Nanoparticles

May 2, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Nanoparticles have been presented. According to news originating from Giza, Egypt, by NewsRx correspondents, research stated, "The purpose of this study was to investigate the effect of acute dosing with silver nanoparticles (AgNPs) and identify potential ultrastructural alterations in the liver and kidney and their effect on blood parameters in the albino rat. Twenty rats were used to assess the acute effects of AgNPs."

Our news journalists obtained a quote from the research from the University of Cairo, "Rats in the treatment group were injected intraperitoneally with 0.5 mL of distilled water containing AgNPs at a dose of 2,000 mg/kg body weight followed by a second injection after 48 hours. Control rats received two 0.5 mL doses of distilled water only. After 3 days, blood samples were collected, and the rat kidneys and livers were extracted and processed for electron microscopy to investigate for hematologic and histopathologic alterations. Renal tubules showed swollen epithelium with cytoplasmic vacuolization, thickening of the basement membrane, and destruction of some mitochondrial cristae. Podocytes showed elongation and swelling of their primary and secondary processes. The basement membrane of the capillary tufts became thicker. The hepatic tissue showed narrowing of the sinusoids, swollen hepatocytes with hypertrophied nucleoli, and accumulation of fat globules in the nucleoplasm and cytoplasm. The hepatic sinusoids showed hypertrophied endothelial and Kupffer. Destructed cristae of some mitochondria, endosomes, and larger lysosomes filled with Ag-NPs were also observed in the Kupffer cells. Significant increases were observed in white blood cell count, lymphocyte count, granulocytes, and hemoglobin. There was a significant increase in serum creatinine, urea, and aspartate and alanine aminotransferases. To the best of the authors' knowledge, the ultrastructural changes in renal and liver tissue observed in this study have not been described before."

According to the news editors, the research concluded: "Our results suggest that injection of AgNPs could have severe cytotoxic effects on the structure and function of these organs."

For more information on this research see: Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat. International Journal of Nanomedicine, 2014;9():1505-1517. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Nanoparticles).

The news correspondents report that additional information may be obtained from O.M.M. Sarhan, Cairo University, Dept. of Zool, Fac Sci, Giza, Egypt.

Keywords for this news article include: Giza, Egypt, Africa, Nanotechnology, Emerging Technologies

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Source: Health & Medicine Week