Single-use functionalised media provides scalable purification performance in cell culture
Emphaze AEX Hybrid Purifiers address the requirement for high purity as early as possible in the manufacturing process. Using innovative anionic ligand technology, the purifier delivers chromatographic adsorption capabilities to reduce soluble and insoluble contaminants that are typically removed by Protein A columns and subsequent purification stages such as host cell proteins (HCP), host cell DNA, and endotoxin. Rapid pressure build on the 0.2um bioburden membrane downstream of the functionalised media signals when ion exchange capacity is saturated, helping to protect against breakthrough of impurities. Early removal of soluble impurities lessens the impact on expensive downstream purification technologies such as the Protein A column.
Emphaze AEX Hybrid Purifiers are easy to use, scalable and offer reproducible performance as there is no scope for channelling or mixing as seen with mobile media. The range is fully disposable eliminating the need for cleaning validation and can be retrofitted into existing hardware platforms.
Hear more about Emphaze AEX Hybrid Purifiers from 3M
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Katherine Barnicoat Beky Cann
3M Purification Division Neesham Public Relations
Tel: +44 (0) 1344 858437 Tel: +44 (0) 1296 628180
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