By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Drugs and Therapies have been presented. According to news originating from Princeton, New Jersey, by NewsRx correspondents, research stated, "The use of fluid bed granulation for drying of pharmaceutical nanoparticulates on micron-sized granule substrates is a relatively new technique, with limited understanding in the current literature of the effects of process parameters on the physical properties of the dried nanoparticle powders. This work evaluated the effects of spray mode, spray rate and atomizing pressure for spray granulation of drug nanosuspensions through a systematic study."
Our news journalists obtained a quote from the research from Princeton University, "Naproxen and a proprietary Novartis compound were converted into nanosuspensions through wet media milling and dried onto a mannitol based substrate using spray granulation. For naproxen, various physical properties of the granules, as well as the in vitro re-dispersion and dissolution characteristics of the nano-crystals, were measured. It was found that the spray mode had the most drastic effect, where top spray yielded smaller re-dispersed particle sizes and faster release rates of drug from granules than bottom spray. This was attributed to the co-current spraying in bottom spray resulting in denser, homogenous films on the substrate. Similar in vitro results were obtained for the proprietary molecule, Compound A. In vivo studies in beagle dogs with Compound A showed no significant difference between the liquid and the dried forms of the nanosuspension in terms of overall AUC, differences were observed in the tmax which correlated with the rank ordering observed from the in vitro dissolution profiles."
According to the news editors, the research concluded: "These findings make spray granulation amenable to the production of powders with desired processing and handling properties, without compromising the overall exposure of the compound under investigation."
For more information on this research see: Spray granulation: importance of process parameters on in vitro and in vivo behavior of dried nanosuspensions. European Journal of Pharmaceutics and Biopharmaceutics, 2013;85(3 Pt B):1046-55. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)
The news correspondents report that additional information may be obtained from C.E. Figueroa, Dept. of Chemical & Biological Engineering, Princeton University, Princeton, NJ, United States (see also Drugs and Therapies).
Keywords for this news article include: Princeton, New Jersey, United States, Drugs and Therapies, North and Central America.
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