By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Pharmacokinetics have been published. According to news originating from Sydney, Australia, by NewsRx correspondents, research stated, "Clinically normal koalas (n=12) received a single dose of 10mg/kg fluconazole orally (p.o.; n=6) or intravenously (i.v.; n=6). Serial plasma samples were collected over 24h, and fluconazole concentrations were determined using a validated HPLC assay."
Our news journalists obtained a quote from the research from the University of Sydney, "A noncompartmental pharmacokinetic analysis was performed. Following i.v. administration, median (range) plasma clearance (CL) and steady-state volume of distribution (V-ss) were 0.31 (0.11-0.55) L/h/kg and 0.92 (0.38-1.40) L/kg, respectively. The elimination half-life (t(1/2)) was much shorter than in many species (i.v.: median 2.25, range 0.98-6.51h; p.o.: 4.69, range 2.47-8.01h), and oral bioavailability was low and variable (median 0.53, range 0.20-0.97). Absorption rate-limited disposition was evident. Plasma protein binding was 39.5 +/- 3.5%. Although fluconazole volume of distribution (V-area) displayed an allometric relationship with other mammals, CL and t(1/2) did not. Allometrically scaled values were approximately sevenfold lower (CL) and sixfold higher (t(1/2)) than observed values, highlighting flaws associated with this technique in physiologically distinct species."
According to the news editors, the research concluded: "On the basis of fAUC/MIC pharmacodynamic targets, fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10mg/kg p.o. every 12h."
For more information on this research see: Pharmacokinetics of fluconazole following intravenous and oral administration to koalas (Phascolarctos cinereus). Journal of Veterinary Pharmacology and Therapeutics, 2014;37(1):90-98. Journal of Veterinary Pharmacology and Therapeutics can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Veterinary Pharmacology and Therapeutics - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2885)
The news correspondents report that additional information may be obtained from L.A. Black, University of Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia. Additional authors for this research include M.B. Krockenberger, B. Kimble and M. Govendir (see also Pharmacokinetics).
Keywords for this news article include: Pharmaceuticals, Sydney, Therapy, Pharmacokinetics, Oral Administration, Australia and New Zealand, Drug Administration Routes
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