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Researchers from University of Illinois Describe Findings in Nanoparticles

February 12, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nanoparticles. According to news reporting out of Chicago, Illinois, by NewsRx editors, research stated, "We have formulated hydrophobic curcurmin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] into stable nanoparticle suspensions (nanocurcumin) to overcome its relatively low bioavailability, high rate of metabolism, and rapid elimination and clearance from the body. Employing the curcumin nanoformulations as the platform, we discovered that curcumin has the potential to alleviate morphine tolerance."

Our news journalists obtained a quote from the research from the University of Illinois, "The two types of stable polymeric nanoparticles, poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), and the hybrid of the two were generated using flash nanoprecipitation integrated with spray drying. The optimized formulations have high drug loading (>45%), small particles size with narrow distribution, and controlled surface properties. Mice behavioral studies (tail-flick and hot-plate tests) were conducted to verify the effects of nanocurcumin on attenuating morphine tolerance. Significant analgesia was observed in mice during both tail-flick and hot-plate tests using orally administered nanocurcumin following subcutaneous injections of morphine. However, unformulated curcumin at the same dose showed no effect."

According to the news editors, the research concluded: "Compared with PEGylated nanocurcumin, negatively charged PLGA nanoparticles showed better functionality."

For more information on this research see: Orally administered nanocurcumin to attenuate morphine tolerance: comparison between negatively charged PLGA and partially and fully PEGylated nanoparticles. Molecular Pharmaceutics, 2013;10(12):4546-51. (American Chemical Society -; Molecular Pharmaceutics -

Our news journalists report that additional information may be obtained by contacting H. Shen, Dept. of Chemical Engineering, University of Illinois at Chicago , Chicago, Illinois 60607, United States. Additional authors for this research include X. Hu, M. Szymusiak, Z.J. Wang and Y. Liu (see also Nanoparticles).

Keywords for this news article include: Chicago, Alkanes, Illinois, Curcumin, Catechols, Hydrocarbons, United States, Nanotechnology, Diarylheptanoids, Organic Chemicals, Emerging Technologies, North and Central America.

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Source: Biotech Week

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