By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Carotenoids are presented in a new report. According to news reporting out of Columbia, South Carolina, by NewsRx editors, research stated, "Retinoids comprise a group of compounds each composed of three basic parts: a trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side chain that functions as a linker unit, and a polar carbon-oxygen functional group. Biochemical conversion of carotenoid or other retinoids to retinoic acid (RA) is essential for normal regulation of a wide range of biological processes including development, differentiation, proliferation, and apoptosis."
Our news journalists obtained a quote from the research from the University of South Carolina, "Retinoids regulate various physiological outputs by binding to nuclear receptors called retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which themselves are DNA-binding transcriptional regulators. The functional response of RA and their receptors are modulated by a host of coactivators and corepressors. Retinoids are essential in the development and function of several organ systems; however, deregulated retinoid signaling can contribute to serious diseases. Several natural and synthetic retinoids are in clinical use or undergoing trials for treating specific diseases including cancer."
According to the news editors, the research concluded: "In this review, we provide a broad overview on the importance of retinoids in development and various diseases, highlighting various retinoids in the drug discovery process, ranging all the way from retinoid chemistry to clinical uses and imaging."
For more information on this research see: Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry, 2014;22(2):673-683. Bioorganic & Medicinal Chemistry can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Bioorganic & Medicinal Chemistry - www.elsevier.com/wps/product/cws_home/129)
Our news journalists report that additional information may be obtained by contacting B.C. Das, University of South Carolina, Dept. of Pathol Microbiol & Immunol, Sch Med, Columbia, SC 29209, United States. Additional authors for this research include P. Thapa, R. Karki, S. Das, S. Mahapatra, T.C. Liu, I. Torregroza, D.P. Wallace, S. Kambhampati, P. Van Veldhuizen, A. Verma, S.K. Ray and T. Evans (see also Carotenoids).
Keywords for this news article include: Alkenes, Therapy, Columbia, Retinoids, Carotenoids, Cyclohexanes, Hydrocarbons, United States, Retinoic Acid, South Carolina, Cycloparaffins, North and Central America
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