By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Quantum Dots have been presented. According to news reporting from Munich, Germany, by NewsRx journalists, research stated, "The paper describes all stages of synthesis and characterization of biocompatible CdSe-based core/shell quantum dots (QDs) and their application as fluorescent label for immunoassay. Special attention was focused on development of maleic anhydride-based amphiphilic polymers for QDs solubilization in aqueous media."
The news correspondents obtained a quote from the research from Technical University, "In this work two PEG-amines were tried for polymer modification: monoamine Jeffamine M1000 used previously in some researches and diamine Jeffamine ED-2003 applied for the first time for QDs solubilization. The use of different Jeffamines allows us to obtain QDs with carboxyl or amine functional groups available for conjugation. The influence of polymer composition on optical properties of the nanocrystals and their stability in aqueous solutions as well as on their conjugation with biomolecules was studied. QDs with different coatings were used as biolabels in quantitative fluorescence microtiter plate immunoassay and qualitative on-site column test. It was found that quantum dots covered with amphiphilic polymer prepared from poly(maleic anhydride-alt-1-octadecene) and Jeffamine ED-2003 retained up to 90% of their initial brightness, easily conjugated with protein and showed low non-specific adsorption."
According to the news reporters, the research concluded: "In optimized conditions the obtained QDs were successfully used for determination of mycotoxin deoxynivalenol in wheat and maize samples by fluorescence microtiter plate immunoassay with an IC50 of 220 mu g kg(-1) and by on-site column test with cut-off of 500 mu g kg(-1)."
For more information on this research see: Polymer-coated fluorescent CdSe-based quantum dots for application in immunoassay. Biosensors & Bioelectronics, 2014;53():225-231. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
Our news journalists report that additional information may be obtained by contacting E.S. Speranskaya, Technical University of Munich, Inst Hydrochem & Chem Balneol, Chair Analyt Chem, D-81377 Munich, Germany. Additional authors for this research include N.V. Beloglazova, P. Lenain, S. De Saeger, Z.H. Wang, S.X. Zhang, Z. Hens, D. Knopp, R. Niessner, D.V. Potapkin and I.Y. Goryacheva (see also Quantum Dots).
Keywords for this news article include: Munich, Europe, Germany, Quantum Dots, Nanotechnology, Quantum Physics, Emerging Technologies
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