By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Fullerenes are presented in a new report. According to news reporting originating in Gyeonggi Do, South Korea, by NewsRx journalists, research stated, "Glycol chitosan (GC) grafted with 2,3-dimethylmaleic acid (DMA) and fullerene (C60) conjugates (GC-g-DMA-g-C60) were developed for use in a photosensitizer prodrug. GC-g-DMA-g-C60 was prepared via the simple two-step chemical grafting reactions of (i) DMA to free amine groups of GC and (ii) hydroxyl groups of GC-g-DMA to ?? carbon bonds of C60."
The news reporters obtained a quote from the research from the Catholic University of Korea, "This conjugate was self-assembled to form polysaccharidic nanogels consisting of a hydrophilic block (GC and DMA) and a hydrophobic block (C60). Here, GC-g-DMA-g-C60 nanogels also formed multi-nanogel aggregates due to the electrostatic interaction between the pendant carboxylic acid group (due to the DMA) and residual free amine group of GC at pH 7.4. Interestingly, the nanogel aggregates can be disintegrated at pH 5.0 due to the reduction of electrostatic interaction resulting from the cleavage of the DMA blocks at pH 5.0. Upon 670nm light illumination, photo-responsive properties of the nanogel aggregates allowed different singlet oxygen generation according to the pH condition: the reduced singlet oxygen generation (due to increased photo-interference effect between C60 molecules close-packed in nanogel aggregates) at pH 7.4, but the elevated singlet oxygen generation (due to the disintegration of nanogel aggregates) at pH 5.0."
According to the news reporters, the research concluded: "GC-g-DMA-g-C60 nanogel aggregates responds to pH 5.0 (approximately endosomal pH) can be a good candidate for endosomal pH targeting and in vivo photodynamic therapy in various malignant tumor cells."
For more information on this research see: Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy. Carbohydrate Polymers, 2014;101():692-8. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)
Our news correspondents report that additional information may be obtained by contacting S. Kim, Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, South Korea. Additional authors for this research include D.J. Lee, D.S. Kwag, U.Y. Lee, Y.S. Youn and E.S Lee (see also Fullerenes).
Keywords for this news article include: Asia, Pharmaceuticals, Carbon, Therapy, Chalcogens, Fullerenes, Gyeonggi Do, South Korea, Nanotechnology, Singlet Oxygen, Emerging Technologies, Reactive Oxygen Species.
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