By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Stem Cell Research are discussed in a new report. According to news reporting originating from Tulsa, Oklahoma, by NewsRx correspondents, research stated, "Bone healing can be significantly expedited by applying electrical stimuli in the injured region. Therefore, a three-dimensional (3D) ceramic conductive tissue engineering -scaffold for large bone defects that can locally deliver the electrical stimuli is highly desired."
Our news editors obtained a quote from the research from Oklahoma State University, "In the present study, 3D conductive scaffolds were prepared by employing a biocompatible conductive polymer, ie, poly(3,4-ethylenedioxythiophene) poly(4-styrene sulfonate) (PEDOT: PSS), in the optimized nanocomposite of gelatin and bioactive glass. For in vitro analysis, adult human mesenchymal stem cells were seeded in the scaffolds. Material characterizations using hydrogen- 1 nuclear magnetic resonance, in vitro degradation, as well as thermal and mechanical analysis showed that incorporation of PEDOT: PSS increased the physiochemical stability of the composite, resulting in improved mechanical properties and biodegradation resistance. The outcomes indicate that PEDOT: PSS and polypeptide chains have close interaction, most likely by forming salt bridges between arginine side chains and sulfonate groups. The morphology of the scaffolds and cultured human mesenchymal stem cells were observed and analyzed via scanning electron microscope, micro-computed tomography, and confocal fluorescent microscope. Increasing the concentration of the conductive polymer in the scaffold enhanced the cell viability, indicating the improved microstructure of the scaffolds or boosted electrical signaling among cells."
According to the news editors, the research concluded: "These results show that these conductive scaffolds are not only structurally more favorable for bone tissue engineering, but also can be a step forward in combining the tissue engineering techniques with the method of enhancing the bone healing by electrical stimuli."
For more information on this research see: 3D conductive nanocomposite scaffold for bone tissue engineering. International Journal of Nanomedicine, 2014;9():167-181. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Stem Cell Research).
The news editors report that additional information may be obtained by contacting A. Shahini, Oklahoma State University, Helmerich Adv Technol Res Center, Sch Mat Sci & Engn, Tulsa, OK, United States. Additional authors for this research include M. Yazdimamaghani, K.J. Walker, M.A. Eastman, H. Hatami-Marbini, B.J. Smith, J.L. Ricci, S.V. Madihally, D. Vashaee and L. Tayebi.
Keywords for this news article include: Biomedical Engineering, Biomedicine, Tulsa, Oklahoma, United States, Bone Research, Bioengineering, Bone Regeneration, Stem Cell Research, Bone-Tissue Engineering, North and Central America
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