By a News Reporter-Staff News Editor at Biotech Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting originating in Bologna, Italy, by NewsRx journalists, research stated, "Structured nanoparticles (NPs) with controlled size distribution and novel physicochemical features present fundamental advantages as drug delivery systems with respect to bulk drugs. NPs can transport and release drugs to target sites with high efficiency and limited side effects."
The news reporters obtained a quote from the research, "Regulatory institutions such as the US Food and Drug Administration (FDA) and the European Commission have pointed out that major limitations to the real application of current nanotechnology lie in the lack of homogeneous, pure and well-characterized NPs, also because of the lack of well-assessed, robust routine methods for their quality control and characterization. Many properties of NPs are size-dependent, thus the particle size distribution (PSD) plays a fundamental role in determining the NP properties. At present, scanning and transmission electron microscopy (SEM, TEM) are among the most used techniques to size characterize NPs. Size-exclusion chromatography (SEC) is also applied to the size separation of complex NP samples. SEC selectivity is, however, quite limited for very large molar mass analytes such as NPs, and interactions with the stationary phase can alter NP morphology. Flow field-flow fractionation (F4) is increasingly used as a mature separation method to size sort and characterize NPs in native conditions. Moreover, the hyphenation with light scattering (LS) methods can enhance the accuracy of size analysis of complex samples."
According to the news reporters, the research concluded: "In this paper, the applications of F4-LS to NP analysis used as drug delivery systems for their size analysis, and the study of stability and drug release effects are reviewed."
For more information on this research see: Flow field-flow fractionation for the analysis of nanoparticles used in drug delivery. Journal of Pharmaceutical and Biomedical Analysis, 2014;87():53-61. Journal of Pharmaceutical and Biomedical Analysis can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Pharmaceutical and Biomedical Analysis - www.elsevier.com/wps/product/cws_home/525434)
Our news correspondents report that additional information may be obtained by contacting A. Zattoni, byFlow Srl, I-40127 Bologna, Italy. Additional authors for this research include B. Roda, F. Borghi, V. Marassi and P. Reschiglian (see also Drugs and Therapies).
Keywords for this news article include: Italy, Europe, Bologna, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies
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