News Column

Reports from Kyushu University Add New Data to Findings in Tissue Engineering

February 14, 2014

By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Biomedicine and Biomedical Engineering. According to news originating from Fukuoka, Japan, by NewsRx correspondents, research stated, "Tissue engineering requires growth factors, cells and a scaffold to permit effective tissue regeneration. This study aimed to develop a scaffold with a focus on immobilizing growth factors within gelatin."

Our news journalists obtained a quote from the research from Kyushu University, "We focused on the extracellular matrix and developed a heparin-conjugated gelatin (Hep-gela). Conjugation was confirmed using the alcian blue assay and X-ray diffraction patterns. The mechanical strength and stability of the Hep-gela gel in protease solution were improved compared with collagen gel. Hep-gela was able to immobilize vascular endothelial growth factor (VEGF) even in the presence of albumin, with an efficiency of 54.2%. Immobilized VEGF promoted proliferation of human umbilical vein endothelial cells. Hep-gela-immobilized VEGF maintained its native biological activity."

According to the news editors, the research concluded: "In summary, Hep-gela has the potential to become an effective material in the field of regenerative medicine."

For more information on this research see: Heparin-conjugated gelatin as a growth factor immobilization scaffold. Journal of Bioscience and Bioengineering, 2013;115(5):562-7. (Elsevier -; Journal of Bioscience and Bioengineering -

The news correspondents report that additional information may be obtained from S. Nakamura, Dept. of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Additional authors for this research include T. Kubo and H. Ijima (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Asia, VEGF, Tissue Engineering, Biomedicine and Biomedical Engineering, Japan, Fukuoka, Bioengineering, Protein Kinases, Membrane Proteins, Angiogenic Proteins, Phosphotransferases, Regenerative Medicine, Growth Factor Receptors, Receptor Protein Tyrosine Kinases, Vascular Endothelial Growth Factors.

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Source: Angiogenesis Weekly

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