By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Biomedicine and Biomedical Engineering. According to news originating from Fukuoka, Japan, by NewsRx correspondents, research stated, "Tissue engineering requires growth factors, cells and a scaffold to permit effective tissue regeneration. This study aimed to develop a scaffold with a focus on immobilizing growth factors within gelatin."
Our news journalists obtained a quote from the research from Kyushu University, "We focused on the extracellular matrix and developed a heparin-conjugated gelatin (Hep-gela). Conjugation was confirmed using the alcian blue assay and X-ray diffraction patterns. The mechanical strength and stability of the Hep-gela gel in protease solution were improved compared with collagen gel. Hep-gela was able to immobilize vascular endothelial growth factor (VEGF) even in the presence of albumin, with an efficiency of 54.2%. Immobilized VEGF promoted proliferation of human umbilical vein endothelial cells. Hep-gela-immobilized VEGF maintained its native biological activity."
According to the news editors, the research concluded: "In summary, Hep-gela has the potential to become an effective material in the field of regenerative medicine."
For more information on this research see: Heparin-conjugated gelatin as a growth factor immobilization scaffold. Journal of Bioscience and Bioengineering, 2013;115(5):562-7. (Elsevier - www.elsevier.com; Journal of Bioscience and Bioengineering - www.elsevier.com/wps/product/cws_home/505516)
The news correspondents report that additional information may be obtained from S. Nakamura, Dept. of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Additional authors for this research include T. Kubo and H. Ijima (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Asia, VEGF, Tissue Engineering, Biomedicine and Biomedical Engineering, Japan, Fukuoka, Bioengineering, Protein Kinases, Membrane Proteins, Angiogenic Proteins, Phosphotransferases, Regenerative Medicine, Growth Factor Receptors, Receptor Protein Tyrosine Kinases, Vascular Endothelial Growth Factors.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC