By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Stem Cell Research are discussed in a new report. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Treatment of myocardial infarction (MI) with adipose-derived stem cells (ASCs) has produced promising results. Cyclosporine A (CsA) inhibits apoptosis by preventing the opening of mitochondrial permeability transition pores."
Our news journalists obtained a quote from the research from the Institute of Geriatric Cardiology, "A CsA nanoparticle emulsion (CsA-NP) has lower toxicity and higher efficiency as compared to CsA. In this study, we hypothesized that a combination of ASCs and CsA-NP would enhance the therapeutic efficiency in a swine MI model. MI was induced in pig hearts by occlusion of the left anterior descending artery. The animals that survived MI were divided into four groups and 1 week later received intracoronary ASCs (ASCs, n=6), intracoronary culture media in combination with CsA-NP (CsA-NP, n=6), intracoronary ASCs in combination with CsA-NP (ASCs + CsA-NP, n=6), or remained untreated (control, n=4). Animals were sacrificed 8 weeks later and were evaluated for cardiac function by delayed-enhanced magnetic resonance imaging and immunohistopathology. We observed that the left ventricular ejection fraction (LVEF) was significantly increased in the ASCs + CsA-NP group, compared to the CsA-NP group (53.6%+/-2.4% versus 48.6%+/-1.5%, P
According to the news editors, the research concluded: "This study demonstrates that CsA-NP enhanced the therapeutic benefits of ASCs transplantation for MI."
For more information on this research see: Cyclosporine A-nanoparticles enhance the therapeutic benefit of adipose tissue-derived stem cell transplantation in a swine myocardial infarction model. International Journal of Nanomedicine, 2014;9():17-26. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Stem Cell Research).
The news correspondents report that additional information may be obtained from Q.X. Yin, Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr Cardiol, Beijing, People's Republic of China. Additional authors for this research include Z.Y. Pei, H. Wang and Y.S. Zhao.
Keywords for this news article include: Asia, Drugs, Beijing, Surgery, Therapy, Treatment, Heart Attack, Nanoparticle, Heart Disease, Nanotechnology, Topical Agents, Cyclic Peptides, Vascular Diseases, Stem Cell Research, Myocardial Ischemia, Cell Transplantation, Emerging Technologies, Myocardial Infarction, Ophthalmic Preparations, Immunosuppressive Agents
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