By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Blood Cells are discussed in a new report. According to news reporting originating in Taoyuan, Taiwan, by NewsRx journalists, research stated, "Incomplete endothelialization, blood cell adhesion to vascular stents, and inflammation of arteries can result in acute stent thromboses. The systemic administration of acetylsalicylic acid decreases endothelial dysfunction, potentially reducing thrombus, enhancing vasodilatation, and inhibiting the progression of atherosclerosis; but, this is weakened by upper gastrointestinal bleeding."
The news reporters obtained a quote from the research from Chang Gung Memorial Hospital, "This study proposes a hybrid stent with biodegradable nanofibers, for the local, sustained delivery of acetylsalicylic acid to injured artery walls. Biodegradable nanofibers are prepared by first dissolving poly(D, L)-lactide-co-glycolide and acetylsalicylic acid in 1,1,1,3,3,3-hexafluoro-2-propanol. The solution is then electrospun into nanofibrous tubes, which are then mounted onto commercially available bare-metal stents. In vitro release rates of pharmaceuticals from nanofibers are characterized using an elution method, and a high-performance liquid chromatography assay. The experimental results suggest that biodegradable nanofibers release high concentrations of acetylsalicylic acid for three weeks. The in vivo efficacy of local delivery of acetylsalicylic acid in reducing platelet and monocyte adhesion, and the minimum tissue inflammatory reaction caused by the hybrid stents in treating denuded rabbit arteries, are documented. The proposed hybrid stent, with biodegradable acetylsalicylic acid-loaded nanofibers, substantially contributed to local, sustained delivery of drugs to promote re-endothelialization and reduce thrombogenicity in the injured artery. The stents may have potential applications in the local delivery of cardiovascular drugs."
According to the news reporters, the research concluded: "Furthermore, the use of hybrid stents with acetylsalicylic acid-loaded nanofibers that have high drug loadings may provide insight into the treatment of patients with high risk of acute stent thromboses."
For more information on this research see: Local sustained delivery of acetylsalicylic acid via hybrid stent with biodegradable nanofibers reduces adhesion of blood cells and promotes reendothelialization of the denuded artery. International Journal of Nanomedicine, 2014;9():311-326. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Blood Cells).
Our news correspondents report that additional information may be obtained by contacting C.H. Lee, Chang Gung Memorial Hospital, Dept. of Anat Pathol, Tao Yuan, Taiwan. Additional authors for this research include Y.H. Lin, S.H. Chang, C.D. Tai, S.J. Liu, Y. Chu, C.J. Wang, M.Y. Hsu, H. Chang, G.J. Chang, K.C. Hung, M.J. Hsieh, F.C. Lin, I.C. Hsieh, M.S. Wen and Y.L. Huang.
Keywords for this news article include: Asia, Taiwan, Taoyuan, Nanofiber, Blood Cells, Nanotechnology, Emerging Technologies
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