News Column

New Findings on Pulmonary Fibrosis from Mayo Clinic Summarized

February 10, 2014



By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators publish new report on Lung Diseases and Conditions. According to news reporting originating in Rochester, Minnesota, by NewsRx journalists, research stated, "Accurate assessment of prognosis in idiopathic pulmonary fibrosis remains elusive due to significant individual radiological and physiological variability. We hypothesised that short-term radiological changes may be predictive of survival."

The news reporters obtained a quote from the research from Mayo Clinic, "We explored the use of CALIPER (Computer-Aided Lung Informatics for Pathology Evaluation and Rating), a novel software tool developed by the Biomedical Imaging Resource Laboratory at the Mayo Clinic Rochester (Rochester, MN, USA) for the analysis and quantification of parenchymal lung abnormalities on high-resolution computed tomography. We assessed baseline and follow-up (time-points 1 and 2, respectively) high-resolution computed tomography scans in 55 selected idiopathic pulmonary fibrosis patients and correlated CALIPER-quantified measurements with expert radiologists' assessments and clinical outcomes. Findings of interval change (mean 289 days) in volume of reticular densities (hazard ratio 1.91, p=0.006), total volume of interstitial abnormalities (hazard ratio 1.70, p = 0.003) and per cent total interstitial abnormalities (hazard ratio 1.52, p=0.017) as quantified by CALIPER were predictive of survival after a median follow-up of 2.4 years. Radiologist interpretation of short-term global interstitial lung disease progression, but not specific radiological features, was also predictive of mortality."

According to the news reporters, the research concluded: "These data demonstrate the feasibility of quantifying interval short-term changes on high-resolution computed tomography and their possible use as independent predictors of survival in idiopathic pulmonary fibrosis."

For more information on this research see: Automated quantification of radiological patterns predicts survival in idiopathic pulmonary fibrosis. European Respiratory Journal, 2014;43(1):204-212. European Respiratory Journal can be contacted at: European Respiratory Soc Journals Ltd, 442 Glossop Rd, Sheffield S10 2PX, England. (Wiley-Blackwell - www.wiley.com/; European Respiratory Journal - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1399-3003)

Our news correspondents report that additional information may be obtained by contacting F. Maldonado, Mayo Clinic, Div Radiol, Rochester, MN, United States. Additional authors for this research include T. Moua, S. Rajagopalan, R.A. Karwoski, S. Raghunath, P.A. Decker, T.E. Hartman, B.J. Bartholmai, R.A. Robb and J.H. Ryu (see also Lung Diseases and Conditions).

Keywords for this news article include: Rochester, Minnesota, Respirology, United States, Imaging Technology, Computed Tomography, North and Central America, Respiratory Tract Diseases, Lung Diseases and Conditions, Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonias

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Source: Respiratory Therapeutics Week


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