By a News Reporter-Staff News Editor at Proteomics Weekly -- Current study results on Proteomics have been published. According to news reporting originating from Victoria, Canada, by NewsRx correspondents, research stated, "Protein surfaces are complex solutes, and protein-protein interactions are specifically mediated by surface motifs that modulate solvation shells in poorly understood ways. We report herein a supramolecular host that is designed to mimic one of the most important recognition motifs that drives protein-protein interactions, the stacked arginine side chain."
Our news editors obtained a quote from the research from the University of Victoria, "We show that it binds its guests and displays good selectivity in the highly competitive medium of pure, buffered water. We use a combination of experimental studies of binding and molecular dynamics simulations to build a cohesive picture of how this biomimetic host achieves the feat. The presence of the stacking element next to the guanidinium groups causes a decrease in the number of host-water hydrogen bonds, a decrease in the density of water around the host, and a decrease in water-water hydrogen bonds near the host. Experimental data using mixed organic/aqueous solvent systems confirm that this host relies on the hydrophobic effect in a way that the two control hosts do not."
According to the news editors, the research concluded: "Our simulations and analysis provide detailed information on the linkage between (de)hydration and binding events in water in a way that could be applied to many aqueous supramolecular systems."
For more information on this research see: Minimalist Synthetic Host with Stacked Guanidinium Ions Mimics the Weakened Hydration Shells of Protein-protein Interaction Interfaces. Journal of Organic Chemistry, 2014;79(1):34-40. Journal of Organic Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Organic Chemistry - www.pubs.acs.org/journal/joceah)
The news editors report that additional information may be obtained by contacting X. Wang, University of Victoria, Dept. of Chem, Victoria, BC V8W 3V6, Canada. Additional authors for this research include J. Post, D.K. Hore and F. Hof (see also Proteomics).
Keywords for this news article include: Canada, Victoria, Proteomics, Nanotechnology, Supramolecular, British Columbia, Protein Interaction, Emerging Technologies, North and Central America
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