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New Findings from University of Iceland in Chalcogens Provides New Insights

February 11, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Chalcogens. According to news reporting originating in Reykjavik, Iceland, by NewsRx journalists, research stated, "5-Aminolevulinic acid (ALA) is a common precursor for tetrapyrrole compounds in all kinds of organisms and has wide applications in agriculture and medicines. In this study, a new strategy, i.e. short-term dissolved oxygen (DO) shock during aerobic fermentation, was introduced to produce 5-aminolevulinic acid with a recombinant E. coli."

The news reporters obtained a quote from the research from the University of Iceland, "Effects of duration time of DO shock operation on plasmid concentration, intracellular ALA synthase (ALAS) activity and ALA production were investigated in Erlenmeyer shake flasks. The results indicated that both ALAS activity and ALA yield were enhanced in an anaerobic operation of 45 min in the early exponential phase during fermentation, while they decreased when the anaerobic operation time was further increased to 60 min."

According to the news reporters, the research concluded: "The DO shock protocol was confirmed with the fed-batch fermentation in a 15 L fermenter and the ALA production achieved 9.4 g.L-1 (72 mmol.L-1), which is the highest yield in the fermentation broth reported up to now."

For more information on this research see: Improved 5-Aminolevulinic Acid Production with Recombinant Escherichia coli by a Short-term Dissolved Oxygen Shock in Fed-batch Fermentation. Chinese Journal of Chemical Engineering, 2013;21(11):1291-1295. Chinese Journal of Chemical Engineering can be contacted at: Chemical Industry Press, No. 3 Huixinli Chaoyangqu, Beijing 100029, Peoples R China. (Elsevier -; Chinese Journal of Chemical Engineering -

Our news correspondents report that additional information may be obtained by contacting J. Yang, University of Iceland, Center Syst Biol, Reykjavik, Iceland. Additional authors for this research include L. Zhu, W.Q. Fu, Y.J. Lin, J.P. Lin and P.L. Cen (see also Chalcogens).

Keywords for this news article include: Europe, Iceland, Reykjavik, Chalcogens, Escherichia coli, Enterobacteriaceae, Gram-Negative Bacteria

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Source: Life Science Weekly

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