News Column

New Findings from S.M. Jay and Co-Researchers in the Area of Cardiovascular Research Described

February 13, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on Cardiovascular Research have been presented. According to news reporting originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "A number of new and innovative approaches for repairing damaged myocardium are currently undergoing investigation, with several encouraging results. In addition to the progression of stem cell-based approaches and gene therapy/silencing methods, evidence continues to emerge that protein therapeutics may be used to directly promote cardiac repair and even regeneration."

Our news editors obtained a quote from the research, "However, proteins are often limited in their therapeutic potential by short local half-lives and insufficient bioavailability and bioactivity, and many academic laboratories studying cardiovascular diseases are more comfortable with molecular and cellular biology than with protein biochemistry. Protein engineering has been used broadly to overcome weaknesses traditionally associated with protein therapeutics and has the potential to specifically enhance the efficacy of molecules for cardiac repair. However, protein engineering as a strategy has not yet been used in the development of cardiovascular therapeutics to the degree that it has been used in other fields. In this review, we discuss the role of engineered proteins in cardiovascular therapies to date."

According to the news editors, the research concluded: "Further, we address the promise of applying emerging protein engineering technologies to cardiovascular medicine and the barriers that must be overcome to enable the ultimate success of this approach."

For more information on this research see: Protein Engineering for Cardiovascular Therapeutics Untapped Potential for Cardiac Repair. Circulation Research, 2013;113(7):933-943. Circulation Research can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Cardiovascular Research).

The news editors report that additional information may be obtained by contacting S.M. Jay, Brigham Regenerat Med Center, Cambridge, MA, United States.

Keywords for this news article include: Biotechnology, Cambridge, Cardiology, Gene Therapy, Massachusetts, United States, Bioengineering, Cardiovascular Research, North and Central America

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Source: Gene Therapy Weekly

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