The news correspondents obtained a quote from the research, "Scanning electron microscopy (SEM) and circular dichroism (CD) pointed out that peptide 1, which contains the shortest C2 linear residue, presented the most defined fibril network and afforded nanoscale helical aggregates. Tetrapeptide 3, with C4 linear residues in its structure, also showed bundles of fibres whereas a homogeneous spherulitic network was observed for tetrapeptide 2, with a C3 spacer between cyclobutane residues. Computational calculations for 1 allowed us to model the self-assembly of the molecules and suggested a head-to-head arrangement to give helical structures corresponding to hydrogen-bonded single chains."
According to the news reporters, the research concluded: "These features were corroborated by a high-resolution NMR spectroscopy study of the dynamics of the gelation process in toluene-d8 which evidenced that molecules self-assemble to afford ordered aggregates with a supramolecular chirality."
For more information on this research see: Low-molecular-weight gelators consisting of hybrid cyclobutane-based peptides. Organic and Biomolecular Chemistry, 2013;11(17):2839-46. (
Our news journalists report that additional information may be obtained by contacting S. Celis, Departament de Quimica,
Keywords for this news article include: Spain,
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