By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on Nanoparticles is the subject of a report. According to news reporting originating in St. Petersburg, Russia, by NewsRx journalists, research stated, "Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with recombinant human epidermal growth factor (SPION-EGF) were studied as a potential agent for magnetic resonance imaging contrast enhancement of malignant brain tumors. Synthesized conjugates were characterized by transmission electron microscopy, dynamic light scattering, and nuclear magnetic resonance relaxometry."
The news reporters obtained a quote from the research from the Russian Academy of Science, "The interaction of SPION-EGF conjugates with cells was analyzed in a C6 glioma cell culture. The distribution of the nanoparticles and their accumulation in tumors were assessed by magnetic resonance imaging in an orthotopic model of C6 gliomas. SPION-EGF nanosuspensions had the properties of a negative contrast agent with high coefficients of relaxation efficiency. In vitro studies of SPION-EGF nanoparticles showed high intracellular incorporation and the absence of a toxic influence on C6 cell viability and proliferation. Intravenous administration of SPION-EGF conjugates in animals provided receptor-mediated targeted delivery across the blood-brain barrier and tumor retention of the nanoparticles; this was more efficient than with unconjugated SPIONs. The accumulation of conjugates in the glioma was revealed as hypotensive zones on T2-weighted images with a twofold reduction in T2 relaxation time in comparison to unconjugated SPIONs (P < 0.001)."
According to the news reporters, the research concluded: "SPION-EGF conjugates provide targeted delivery and efficient magnetic resonance contrast enhancement of EGFR-overexpressing C6 gliomas."
For more information on this research see: Superparamagnetic iron oxide nanoparticles conjugated with epidermal growth factor (SPION-EGF) for targeting brain tumors. International Journal of Nanomedicine, 2014;9():273-287. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Nanoparticles).
Our news correspondents report that additional information may be obtained by contacting M.A. Shevtsov, Russian Academy Sci, IM Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg 194064, Russia. Additional authors for this research include B.P. Nikolaev, L.Y. Yakovleva, Y.Y. Marchenko, A.V. Dobrodumov, A.L. Mikhrina, M.G. Martynova, O.A. Bystrova, I.V. Yakovenko and A.M. Ischenko.
Keywords for this news article include: Russia, Eurasia, St. Petersburg, Nanotechnology, Emerging Technologies
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