News Column

New Endothelial Cells Study Findings Have Been Reported by D. Guarnieri and Colleagues

February 14, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Endothelial Cells. According to news reporting originating in Lecce, Italy, by NewsRx journalists, research stated, "Silica nanoparticles could be promising delivery vehicles for drug targeting or gene therapy. However, few studies have been undertaken to determine the biological behavior effects of silica nanoparticles on primary endothelial cells."

The news reporters obtained a quote from the research, "Here we investigated uptake, cytotoxicity and angiogenic properties of silica nanoparticle with positive and negative surface charge and sizes ranging from 25 to 115 nm in primary human umbilical vein endothelial cells. Dynamic light scattering measurements and nanoparticle tracking analysis were used to estimate the dispersion status of nanoparticles in cell culture media, which was a key aspect to understand the results of the in vitro cellular uptake experiments. Nanoparticles were taken up by primary endothelial cells in a size-dependent manner according to their degree of agglomeration occurring after transfer in cell culture media. Functionalization of the particle surface with positively charged groups enhanced the in vitro cellular uptake, compared to negatively charged nanoparticles. However, this effect was contrasted by the tendency of particles to form agglomerates, leading to lower internalization efficiency. Silica nanoparticle uptake did not affect cell viability and cell membrane integrity. More interestingly, positively and negatively charged 25 nm nanoparticles did not influence capillary-like tube formation and angiogenic sprouting, compared to controls."

According to the news reporters, the research concluded: "Considering the increasing interest in nanomaterials for several biomedical applications, a careful study of nanoparticle-endothelial cells interactions is of high relevance to assess possible risks associated to silica nanoparticle exposure and their possible applications in nanomedicine as safe and effective nanocarriers for vascular transport of therapeutic agents."

For more information on this research see: Effect of silica nanoparticles with variable size and surface functionalization on human endothelial cell viability and angiogenic activity. Journal of Nanoparticle Research, 2014;16(2):1-14. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer -; Journal of Nanoparticle Research -

Our news correspondents report that additional information may be obtained by contacting D. Guarnieri, Ist Italiano Tecnol, Center Biomol Nanotechnol Unile, I-73010 Lecce, Italy. Additional authors for this research include M.A. Malvindi, V. Belli, P.P. Pompa and P. Netti (see also Endothelial Cells).

Keywords for this news article include: Lecce, Italy, Europe, Nanoparticle, Therapeutics, Nanotechnology, Endothelial Cells, Silicon Nanocrystals, Emerging Technologies

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Source: Health & Medicine Week

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