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Investigators from Rensselaer Polytechnic Institute Target Anions

February 11, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Anions. According to news reporting out of Troy, New York, by NewsRx editors, research stated, "Zinc oxide (ZnO) nanoparticles (NPs) have been found to readily react with phosphate ions to form zinc phosphate (Zn-3(PO4)(2)) crystallites. Because phosphates are ubiquitous in physiological fluids as well as waste water streams, it is important to examine the potential effects that the formation of Zn-3(PO4)(2) crystallites may have on cell viability."

Our news journalists obtained a quote from the research from Rensselaer Polytechnic Institute, "Thus, the cytotoxic response of NIH/3T3 fibroblast cells was assessed following 24h of exposure to ZnO NPs suspended in media with and without the standard phosphate salt supplement. Both particle dosage and size have been shown to impact the cytotoxic effects of ZnO NPs, so doses ranging from 5 to 50 mu g/mL were examined and agglomerate size effects were investigated by using the bioinert amphiphilic polymer polyvinylpyrrolidone (PVP) to generate water-soluble ZnO ranging from individually dispersed 4 nm NPs up to micron-sized agglomerates. Cell metabolic activity measures indicated that the presence of phosphate in the suspension media can led to significantly reduced cell viability at all agglomerate sizes and at lower ZnO dosages. In addition, a reduction in cell viability was observed when agglomerate size was decreased, but only in the phosphate-containing media. These metabolic activity results were reflected in separate measures of cell death via the lactate dehydrogenase assay. Our results suggest that, while higher doses of water-soluble ZnO NPs are cytotoxic, the presence of phosphates in the surrounding fluid can lead to significantly elevated levels of cell death at lower ZnO NP doses. Moreover, the extent of this death can potentially be modulated or offset by tuning the agglomerate size."

According to the news editors, the research concluded: "These findings underscore the importance of understanding how nanoscale materials can interact with the components of surrounding fluids so that potential adverse effects of such interactions can be controlled."

For more information on this research see: Phosphate-enhanced cytotoxicity of zinc oxide nanoparticles and agglomerates. Toxicology Letters, 2014;225(1):177-184. Toxicology Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier -; Toxicology Letters -

Our news journalists report that additional information may be obtained by contacting W.N. Everett, Rensselaer Polytechnic Inst, Troy, NY 12180, United States. Additional authors for this research include C. Chern, D.Z. Sun, R.E. McMahon, X. Zhang, W.J.A. Chen, M.S. Hahn and H.J. Sue (see also Anions).

Keywords for this news article include: Troy, Anions, New York, Phosphates, United States, Phosphoric Acids, North and Central America

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Source: Life Science Weekly

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