By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Oncology. According to news originating from Chongqing, People's Republic of China, by NewsRx correspondents, research stated, "The existing evidence that nanobacteria (NB) are closely associated with human disease is overwhelming. However, their potential toxicity against cancer cells has not yet been reported."
Our news journalists obtained a quote from the research from Peoples Hospital, "The objective of this study was to investigate the cytotoxic effects of NB and nano-hydroxyapatites (nHAPs) against human breast cancer cells and to elucidate the mechanisms of action underlying their cytotoxicity. Methodology/principal findings: NB were isolated from calcified placental tissue, and nHAPs were artificially synthesized. The viability of the MDA-MB-231 human breast cancer cell line was tested by using the Kit-8 cell counting kit assay. Apoptosis was examined by transmission electron microscopy and flow cytometry. The endocytosis of NB and nHAPs by MDA-MB-231 cells was initially confirmed by microscopy. Although both NB and nHAPs significantly decreased MDA-MB-231 cell viability and increased the population of apoptotic cells, NB were more potent than nHAPs. After 72 hours, NB also caused ultrastructural changes typical of apoptosis, such as chromatin condensation, nuclear fragmentation, nuclear dissolution, mitochondrial swelling, and the formation of apoptotic bodies. In MDA-MB-231 human breast cancer cells, NB and nHAPs exerted cytotoxic effects that were associated with the induction of apoptosis. The effects exerted by NB were more potent than those induced by nHAPs. NB cytotoxicity probably emerged from toxic metabolites or protein components, rather than merely the hydroxyapatite shells."
According to the news editors, the research concluded: "NB divided during culturing, and similar to cells undergoing binary fission, many NB particles were observed in culture by transmission electron microscopy, suggesting they are live microorganisms."
For more information on this research see: Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells. International Journal of Nanomedicine, 2014;9():265-271. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).
The news correspondents report that additional information may be obtained from M.J. Zhang, First Peoples Hosp Jiulongpo Dist, Chongqing, People's Republic of China. Additional authors for this research include S.N. Liu, G. Xu, Y.N. Guo, J.N. Fu and D.C. Zhang.
Keywords for this news article include: Asia, Oncology, Chongqing, Apoptosis, Nanobacteria, Breast Cancer, Nanotechnology, Women's Health, Emerging Technologies, People's Republic of China
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