By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Bone Research have been published. According to news reporting from New York City, New York, by NewsRx journalists, research stated, "To test if osteoporosis alters mechanical load-induced interstitial fluid flow in bone, this study examined the combined effect of estrogen deficiency and external loading on solute transport around osteocytes. An in vivo tracer, FITC-labeled bovine serum albumin, was injected into anesthetized ovariectomized and control female Sprague-Dawley rats before the right tibia was subjected to a controlled, physiological, non-invasive sinusoidal load to mimic walking."
The news correspondents obtained a quote from the research from Hospital for Special Surgery, "Tracer movement through the lacunar-canalicular system surrounding osteocytes was quantified in cortical and cancellous bone from the proximal tibia using confocal microscopy, with the non-loaded tibia serving as internal control. Overall, the application of mechanical loading increased the percentage of osteocyte lacunae labeled with injected tracer, and ovariectomy further enhanced movement of tracer. An analysis of separate regions demonstrated that ovariectomy enhanced in vivo transport of the injected tracer in the cancellous bone of the tibial epiphysis and metaphysis but not in the cortical bone of the metaphysis. These findings show that bone changes due to reduced estrogen levels alter convectional transport around osteocytes in cancellous bone and demonstrate a functional difference of interstitial fluid flow around osteocytes in estrogen-deficient rats undergoing the same physical activity as controls."
According to the news reporters, the research concluded: "The altered interstitial fluid flow around osteocytes is likely related to nanostructural matrix-mineral level differences recently demonstrated at the lacunar-canalicular surface of estrogen-deficient rats, which could affect the transmission of mechanical loads to the osteocyte."
For more information on this research see: Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone. Bone, 2014;59():229-234. Bone can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Bone - www.elsevier.com/wps/product/cws_home/525233)
Our news journalists report that additional information may be obtained by contacting C. Ciani, Hospital for Special Surgery, Div Res, New York, NY 10021, United States. Additional authors for this research include D. Sharma, S.B. Doty and S.P. Fritton (see also Bone Research).
Keywords for this news article include: New York City, United States, Bone Research, North and Central America
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