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Investigators at Fourth Military Medical University Report Findings in Controlled Release

February 11, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Controlled Release. According to news originating from Xi'an, People's Republic of China, by NewsRx correspondents, research stated, "Reduction-controlled release is favored for many applications. The cleavage of disulfide bonds is known to be sensitive to reducing agents."

Our news journalists obtained a quote from the research from Fourth Military Medical University, "Here, a cross-linker containing a disulfide bond is prepared and then used to prepare cross-linked porous polymer via an emulsion templating approach. Oil-in-water (O/W) emulsions are first formed where an organic dye is dissolved in the oil droplet phase and monomer/cross-linker/surfactant are added into the continuous aqueous phase. By polymerizing the O/W emulsion followed by freeze-drying, organic nanoparticles are formed in situ within the disulfide-crosslinked porous polymer. The release of organic nanoparticles in water is demonstrated and can be tuned by the presence of reducing agents such as dithiothreitol and tris(2-carboxyethyl)phospine."

According to the news editors, the research concluded: "This approach has the potential to be used for the reduction-controlled release of poorly water-soluble drug nanoparticles from porous polymers or hydrogels."

For more information on this research see: Reduction-Controlled Release of Organic Nanoparticles from Disulfide Cross-linked Porous Polymer. Industrial & Engineering Chemistry Research, 2014;53(1):246-252. Industrial & Engineering Chemistry Research can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Industrial & Engineering Chemistry Research -

The news correspondents report that additional information may be obtained from N. Grant, Fourth Military Medical University, Sch Pharm, Dept. of Pharmaceut Chem & Pharmaceut Anal, Xian 710032, People's Republic of China. Additional authors for this research include H. Wu and H.F. Zhang (see also Controlled Release).

Keywords for this news article include: Asia, Ions, Xi'an, Disulfides, Electrolytes, Nanoparticle, Nanotechnology, Controlled Release, Inorganic Chemicals, Emerging Technologies, People's Republic of China

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Source: Life Science Weekly

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