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Findings on Clinical and Randomized Controlled Trials Reported by Researchers at Swinburne University of Technology

February 14, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Clinical Research. According to news reporting out of Melbourne, Australia, by NewsRx editors, research stated, "Age-related cognitive decline (ARCD) is of major societal concern in an ageing population, with the development of dietary supplements providing a promising avenue for amelioration of associated deficits. Despite initial interest in the use of phospholipids (PLs) for ARCD, in recent years there has been a hiatus in such research."

Our news journalists obtained a quote from the research from the Swinburne University of Technology, "Because of safety concerns regarding PLs derived from bovine cortex, and the equivocal efficacy of soybean-derived PLs, there is an important need for the development of new PL alternatives. Phospholipids derived from milk proteins represent one potential candidate treatment. In order to reduce the effects of age-associated memory impairment (AAMI) the Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR) was developed to test the efficacy of a milk protein concentrate rich in natural, non-synthetic milk phospholipids (LacprodanŽ PL-20). PLICAR is a randomized, double-blind, placebo-controlled parallel-groups study where 150 (N=50/group) AAMI participants aged >55 years will be randomized to receive a daily supplement of LacprodanŽ PL-20 or one of two placebos (phospholipid-free milk protein concentrate or inert rice starch) over a 6-month (180-day) period. Participants will undergo testing at baseline, 90 days and 180 days. The primary outcome is a composite memory score from the Rey Auditory Verbal Learning Test. Secondary outcomes include cognitive (verbal learning, working memory, prospective and retrospective memory, processing speed and attention), mood (depression, anxiety, stress and visual analogue scales), cardiovascular (blood pressure, blood velocity and pulse wave pressure), gastrointestinal microbiota and biochemical measures (oxidative stress, inflammation, B vitamins and Homocysteine, glucoregulation and serum choline). Allelic differences in the Apolipoprotein E and (APOE) and Methylenetetrahydrofolate reductase (MTHFR) gene will be included for subgroup analysis. A subset (N=60; 20/group)) will undergo neuroimaging using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in order to further explore in vivo central mechanisms of action of LacprodanŽ PL-20. This study will enable evaluation of the efficacy of milk-derived phospholipids for AAMI, and their mechanisms of action."

According to the news editors, the research concluded: "The trial is jointly funded by Arla Foods and Swinburne University of Technology, currently recruiting and is registered on the Australian New Zealand Clinical Trials Registry as ACTRN12613000347763."

For more information on this research see: A randomized controlled trial investigating the neurocognitive effects of LacprodanŽ PL-20, a phospholipid-rich milk protein concentrate, in elderly participants with age-associated memory impairment: the Phospholipid Intervention for Cognitive Ageing Re. Trials, 2013;14():404. (BioMed Central -; Trials -

Our news journalists report that additional information may be obtained by contacting A.B. Scholey, Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne 3122, Victoria, Australia. Additional authors for this research include D.A. Camfield, M.E. Hughes, W. Woods, C.K. K Stough, D.J. White, S.V. Gondalia and P.D Frederiksen (see also Clinical Research).

Keywords for this news article include: Melbourne, Clinical Research, Australia and New Zealand.

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Source: Health & Medicine Week

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