By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "It is well recognized that the primary interaction of most biological environments with nanoparticles (NPs) is strongly influenced by a long-lived ('hard') protein corona that surrounds the NP and remains strongly adsorbed to its surface. The amount and composition of associated proteins in the corona adsorbed onto the NPs is related to several important factors, including the physicochemical properties of the NPs and the composition of the protein solution."
The news reporters obtained a quote from the research from the K.N. Toosi University of Technology, "Here, for the first time, it is shown that plasmonic heat induction (by laser activation) leads to significant changes in the composition of the hard protein corona adsorbed on low aspect ratio gold nanorods. Using mass spectrometry, several proteins in the corona were identified whose concentrations change most substantially as a result of photoinduced (plasmonic) heating versus simple thermal heating. Molecular modeling suggests that the origin of these changes in protein adsorption may be the result of protein conformational changes in response to much higher local temperatures that occur near the gold nanorods during photoinduced, plasmonic heating. These results may define new applications in vivo for NPs with hyperthermia capability and better define the likely interactions of cells with NPs after plasmonic heating."
According to the news reporters, the research concluded: "Potential changes in the protein corona following hyperthermia treatment may influence the final biological fate of plasmonic NPs in clinical applications and help elucidate safety considerations for hyperthermia applications."
For more information on this research see: Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating. Nano Letters, 2014;14(1):6-12. Nano Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Nano Letters - www.pubs.acs.org/journal/nalefd)
Our news correspondents report that additional information may be obtained by contacting M. Mahmoudi, KN Toosi Univ Technol, Fac Mech Engn, Tehran, Iran. Additional authors for this research include S.E. Lohse, C.J. Murphy, A. Fathizadeh, A. Montazeri and K.S. Suslick (see also Nanoparticles).
Keywords for this news article include: Iran, Asia, Tehran, Nanorod, Nanotechnology, Gold Nanoparticles, Emerging Technologies
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