By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Life Science Research. According to news reporting out of Indianapolis, Indiana, by NewsRx editors, research stated, "Ion conduction through microscopic channels is of central importance in both biology and nanotechnology. To better understand the current-voltage (I-V) dependence of ion channels, here we describe and prove a collective diffusion model that quantitatively relates the spontaneous ion permeation at equilibrium to the stationary ionic fluxes driven by small voltages."
Our news journalists obtained a quote from the research from Indiana University-Purdue University, "The model makes it possible to determine the channel conductance in the linear I-V range from equilibrium simulations without the application of a voltage. To validate the theory, we perform molecular-dynamics simulations on two channels-a conical-shaped nanopore and the transmembrane pore of an ?-hemolysin-under both equilibrium and nonequilibrium conditions. The simulations reveal substantial couplings between the motions of cations and anions, which are effectively captured by the collective coordinate in the model. Although the two channels exhibit very different linear ranges in the I-V curves, in both cases the channel conductance at small voltages is in reasonable agreement with the prediction from the equilibrium simulation."
According to the news editors, the research concluded: "The simulations also suggest that channel charges, rather than geometric asymmetry, play a more prominent role in current rectification."
For more information on this research see: Collective diffusion model for ion conduction through microscopic channels. Biophysical Journal, 2013;104(2):368-76. (Elsevier - www.elsevier.com; Biophysical Journal - www.elsevier.com/wps/product/cws_home/716950)
Our news journalists report that additional information may be obtained by contacting Y. Liu, Dept. of Physics, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States (see also Life Science Research).
Keywords for this news article include: Indianapolis, United States, Life Science Research, North and Central America.
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