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Findings from Australian National University Provides New Data about Enzymes and Coenzymes

February 11, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Enzymes and Coenzymes. According to news reporting out of Canberra, Australia, by NewsRx editors, research stated, "Annually thousands of people die or suffer from organophosphate (pesticide) poisoning. In order to remove these toxic compounds from the environment, the use of enzymes as bioremediators has been proposed."

Our news journalists obtained a quote from the research from Australian National University, "We report here a Ser127Ala mutant based on the enzyme glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. The mutant, with improved metal binding abilities, has been immobilized using glutaraldehyde on PAMAM dendrimer-modified magnetite nanoparticles. The immobilized system was characterized using elemental analysis as well as infrared, transmission electron and X-ray photoelectron spectroscopies. The amount of GpdQ that was immobilized with the optimized procedure was 1.488 nmol per g MNP. A kinetic assay has been designed to evaluate the activity of the system towards organophosphoester substrates."

According to the news editors, the research concluded: "The specific activity towards BPNPP directly after immobilization was 3.55 mu mol mg(-1) min(-1), after one week 3.39 mu mol mg(-1) min(-1) and after 120 days 3.36 mu mol mg(-1) min(-1), demonstrating that the immobilized enzyme was active for multiple cycles and could be stored on the nanoparticles for a prolonged period."

For more information on this research see: Immobilization of the enzyme GpdQ on magnetite nanoparticles for organophosphate pesticide bioremediation. Journal of Inorganic Biochemistry, 2014;131():1-7. Journal of Inorganic Biochemistry can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Journal of Inorganic Biochemistry -

Our news journalists report that additional information may be obtained by contacting L.J. Daumann, Australian National University, Res Sch Chem, Canberra, ACT 0200, Australia. Additional authors for this research include J.A. Larrabee, D. Ollis, G. Schenk and L.R. Gahan (see also Enzymes and Coenzymes).

Keywords for this news article include: Canberra, Pesticides, Nanoparticle, Agrochemicals, Nanotechnology, Emerging Technologies, Enzymes and Coenzymes, Australia and New Zealand

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Source: Life Science Weekly

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