-- The company is involved in the EUREKA project that promotes strategic collaboration of industrial R&D
DANDRILYS(R) is developed from the bark of Ziziphus joazeiro, an evergreen plant native to
The bark extract contains jujubosides, a type of saponin that confers foaming properties and antioxidative protection, with strengthening and revitalizing effects on the skin. Additionally, its sugar constituents comprising polysaccharides and oligosaccharides offer moisturizing and calming effects, which will lower the irritation caused by dandruff.
GREENTECH is the coordinator of the EUREKA project E! 2314 O'SCREEN, which aims to develop a comprehensive database of 30,000 plants with details of their botanical physiology, chemical constituents, and potential applications. Based on reversing the screening process traditionally used in drug discovery, the approach begins by identifying key enzymes involved in certain diseases or disorders. Following this, the project team evaluates and identifies the chemical ligands that could bind to the enzyme to modulate the pathogenesis of the pathway.
"GREENTECH's anti-dandruff promotion strategy is based on the ability of DANDRILYS(R) to cleanse the scalp and hair of impurities and dandruff by preventing sebum production," said Frost & Sullivan Industry Manager for Health and Wellness Sandhya Kamath. "By retarding the production of 5-lipoxygenase (5-LOX), it will inhibit the cascading reactions that trigger itchiness and inflammation."
One of the main catalysts of dandruff is mast cells. These cells cause allergic reactions due to the crosslinking of their surface receptors, FceRI and IgE. The interaction of mast cells with FceRI and IgE lead to degranulation and the release of vasoactive peptides - pro-inflammatory mediators that include histamine, cytokines, and proteolytic enzymes. DANDRILYS(R) is an ideal antidote to this process as it inhibits the degranulation of mast cells, which prevents the subsequent release of histamine, a major mediator that causes itching.
According to the in vitro test by GREENTECH, 2 percent DANDRILYS(R) reduces 27 percent histamine production. Furthermore, the in vivo study of DANDRILYS(R) demonstrated that it reduced dandruff quantity by as much as 67 percent after the first application of the shampoo that contained 2.5 percent DANDRILYS(R).
"By leveraging its comprehensive drug discovery database, GREENTECH has successfully developed an extremely efficient anti-dandruff product that is having a huge impact on the hair care segment," noted Kamath. "Consumers have shown a marked preference for naturally-derived products in recent years; therefore, DANDRILYS(R) may offer an additional option of anti-dandruff actives."
GREENTECH: An innovative concept for the future.
Since 1992, GREENTECH has been developing and producing active ingredients from plants, algae, micro-algae and biotechnology in the cosmetic, nutraceutical and pharmaceutical fields. Present in more than 30 countries, GREENTECH has its portfolio constantly updated by innovative actives and extracts (BIOTILYS(R), QT40(R), SILIDINE(R)…).
Active ingredients from local and worldwide raw materials for local and top cosmetic companies are daily produced in our factories with guarantee of quality (pharmacy and cosmetic GMP compliance).
The R&D laboratory has got its own large database (30 000 plants - 300 000 biological molecules), uses bio-informatics for rapid and targeted development of new actives, and collaborates with scientists and specialists in international research programmes for innovation. Then, GREENTECH was the first company to supply cosmetic ingredients certified Organic by ECOCERT (
Finally, for more than 15 years, GREENTECH has got close and official cooperations with local people in different countries (as
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